- S.C.A.T.: Special Cybernetic Attack Team (NES)
- Saber Rider And The Star Sheriffs (3DS eShop)
- Saboteur! (Switch eShop)
- Sacrilegium (Wii U)
- Sadame (3DS eShop)
- Safari Quest (3DS eShop)
- Safecracker (DS)
- SaGa: Scarlet Grace – Hiiro no Yabou (Switch)
- Saints Row: Drive-By (3DS)
- Saints Row: The Third (Switch)
- Sakura Samurai: Art of the Sword (3DS eShop)
- Sakura Wars: So Long, My Love (Wii)
- Sally's Law (Switch eShop)
- Salt and Sanctuary (Switch eShop)
- Salvaged (Wii U eShop)
- Sam & Max Beyond Time and Space (Wii)
- Sam & Max: Season One (Wii)
- Samba De Amigo (Wii)
- Samurai Aces (Switch eShop)
- Samurai Defender (3DS eShop)
- Samurai Defender: Ninja Warfare (Switch eShop)
- Samurai G (3DS eShop)
- Samurai Ghost (TG-16)
- Samurai Gun 2 (Switch eShop)
- Samurai Jack: The Shadow of Aku (GCN)
- Samurai Shodown (Neo Geo)
- Samurai Shodown Anthology (Wii)
- Samurai Shodown II (Neo Geo)
- Samurai Shodown III (Neo Geo)
- Samurai Shodown IV (Neo Geo)
- Samurai Shodown V (Neo Geo)
- Samurai Sword Destiny (3DS eShop)
- Samurai Warriors 3 (Wii)
- Samurai Warriors 4 DX (Switch)
- Samurai Warriors Chronicles 3 (3DS)
- Samurai Warriors: Chronicles (3DS)
- Samurai Warriors: KATANA (Wii)
- Samurai Warriors: Spirit of Sanada (Switch)
- Sanatory Hallways (Wii U eShop)
- Sands of Destruction (DS)
- Sandy Beach (WiiWare)
- Sangokushi Taisen Ten (DS)
- Sanrio characters Picross (3DS eShop)
- Santa Factory (Wii U eShop)
- Santa Tracker (Switch eShop)
- Saturday Morning RPG (Switch eShop)
- Sausage Sports Club (Switch eShop)
- Savage Reign (Neo Geo)
- Save me Mr Tako: Tasukete Tako-San (Switch eShop)
- Save the Furries (WiiWare)
- Save the Ninja Clan (Switch eShop)
- Save the Turtles (DSiWare)
- Scalextric (Switch eShop)
- Scarygirl Illustration Kit (3DS eShop)
- Schlag den Raab (Wii)
- Schlag den Raab - Das 2. Spiel (Wii)
- Schlag den Raab - Das 2. Spiel (3DS)
- Schlag den Raab - Das 3. Spiel (Wii)
- Schlag den Star (Switch)
- Scooby Doo & Looney Tunes Cartoon Universe: Adventure (3DS)
- Scooby-Doo! and the Spooky Swamp (Wii)
- Scooby-Doo! and the Spooky Swamp (DS)
- Scoop'n Birds (New 3DS)
- Scrabble Classic (DSiWare)
- Scrabble Slam! (DSiWare)
- Scrabble Tools (DSiWare)
- Scram Kitty and his Buddy on Rails (Wii U eShop)
- Screencheat: Unplugged (Switch eShop)
- Scribble (Wii U eShop)
- Scribblenauts (DS)
- Scribblenauts Mega Pack (Switch)
- Scribblenauts Unlimited (Wii U)
- Scribblenauts Unlimited (3DS)
- Scribblenauts Unmasked: A DC Comics Adventure (Wii U)
- Scribblenauts Unmasked: A DC Comics Adventure (3DS)
- Scribblenauts: Showdown (Switch)
- SD Gundam Dimension War (VB)
- SD Gundam G Generation Genesis (Switch eShop)
- SDK Paint (Wii U eShop)
- SDK Spriter (Wii U eShop)
- Sea Battle (DSiWare)
- Season Match (Switch eShop)
- Seasons of Heaven (Switch eShop)
- Secret Agent Barbie: Royal Jewels Mission (GBA)
- Secret Agent Files: Miami (3DS eShop)
- Secret Command (SMS)
- Secret Empires of the Ancient World (3DS eShop)
- Secret Files 2: Puritas Cordis (Wii)
- Secret Files 2: Puritas Cordis (DS)
- Secret Files: Tunguska (Wii U eShop)
- Secret Files: Tunguska (Switch eShop)
- Secret Journeys: Cities of the World (3DS eShop)
- Secret Mysteries in London (3DS)
- Secret Mysteries in New York (3DS eShop)
- Secret of Evermore (SNES)
- Secret of Mana (SNES)
- Secrets of the Titanic 1912-2012 (3DS eShop)
- SEGA 3D Classics Collection (3DS)
- Sega 3D Fukkoku Archives 3: Final Stage (3DS)
- SEGA AGES Out Run (Switch eShop)
- SEGA AGES Phantasy Star (Switch eShop)
- SEGA AGES Sonic The Hedgehog (Switch eShop)
- SEGA AGES Sonic The Hedgehog 2 (Switch eShop)
- SEGA AGES Thunder Force IV (Switch eShop)
- SEGA AGES Virtua Racing (Switch eShop)
- SEGA Bass Fishing (Wii)
- SEGA Mega Drive Classics (Switch)
- Sega Soccer Slam (GCN)
- SEGA Superstars Tennis (Wii)
- SEGA Superstars Tennis (DS)
- Seiken Densetsu 3 (SNES)
- Seiken Densetsu Collection (Switch)
- Semblance (Switch eShop)
- Semispheres (Switch eShop)
- Sengoku (Neo Geo)
- Sengoku 2 (Neo Geo)
- Sengoku 3 (Neo Geo)
- Sengoku BASARA Samurai Heroes (Wii)
- SENRAN KAGURA 2: Deep Crimson (3DS)
- Senran Kagura Burst (3DS)
- Senran Kagura Reflexions (Switch eShop)
- Serial Cleaner (Switch eShop)
- Seven Knights (Switch eShop)
- Severed (Wii U eShop)
- Severed (3DS eShop)
- Severed (Switch eShop)
- Sexy Poker (WiiWare)
- Shadow Archer (Wii U eShop)
- Shadow Archery (Wii U eShop)
- Shadow Bug (Switch eShop)
- Shadow Dancer: The Secret of Shinobi (MD)
- Shadow Fight 2 (Switch eShop)
- Shadow Man (N64)
- Shadow of Loot Box (Switch eShop)
- Shadow of the Eternals (Wii U eShop)
- Shadow of the Ninja (NES)
- Shadow Puppeteer (Wii U eShop)
- Shadow The Hedgehog (GCN)
- Shadowgate (Switch)
- Shadowgun Legends (Switch eShop)
- ShadowPlay (WiiWare)
- Shadowrun (SNES)
- Shadows of Adam (Switch eShop)
- Shakedown Hawaii (3DS eShop)
- Shakedown Hawaii (Switch eShop)
- Shanghai DS (DS)
- Shanghai II: Dragon's Eye (MD)
- Shanghai Mahjong (3DS eShop)
- Shanghai Wii (Wii)
- Shantae (GBC)
- Shantae And The Pirate's Curse (3DS eShop)
- Shantae And The Pirate's Curse (Wii U eShop)
- Shantae and the Pirate's Curse (Switch eShop)
- Shantae: Half-Genie Hero (Wii U)
- Shantae: Half-Genie Hero (Switch eShop)
- Shantae: Risky's Revenge (DSiWare)
- Shantae: Risky's Revenge - Director's Cut (Wii U eShop)
- Shantae: Risky's Revenge – Director's Cut (3DS eShop)
- Shape Of The World (Switch eShop)
- Shapes of Gray (Wii U eShop)
- Shapo (DSiWare)
- Shaq-Fu: A Legend Reborn (Switch)
- Shaun White Snowboarding (DS)
- Shaun White Snowboarding: Road Trip (Wii)
- Shawn Johnson Gymnastics (DSiWare)
- Shütshimi (Wii U eShop)
- Shelter Generations (Switch eShop)
- Sheltered (Switch eShop)
- Shephy (Switch eShop)
- Sherlock Holmes and The Mystery of the Frozen City (3DS)
- Shift DX (3DS eShop)
- Shift Happens (Switch eShop)
- Shift Quantum (Switch eShop)
- Shifting World (3DS)
- Shiftlings (Wii U eShop)
- Shiftlings - Enhanced Edition (Switch eShop)
- Shikhondo - Soul Eater (Switch)
- Shin Megami Tensei IV (3DS)
- Shin Megami Tensei IV: Apocalypse (3DS)
- Shin Megami Tensei V (Switch)
- Shin Megami Tensei: Devil Summoner: Soul Hackers (3DS)
- Shin Megami Tensei: Devil Survivor 2 (DS)
- Shin Megami Tensei: Devil Survivor 2 Record Breaker (3DS)
- Shin Megami Tensei: Devil Survivor Overclocked (3DS)
- Shin Megami Tensei: Strange Journey (DS)
- Shin Megami Tensei: Strange Journey Redux (3DS)
- Shin Nekketsu Kōha: Kunio-tachi no Banka (SNES)
- Shining Force (MD)
- Shining Force Feather (DS)
- Shining Force Gaiden: Final Conflict (GG)
- Shining Force II: Ancient Sealing (MD)
- Shining Force: The Sword of Hajya (GG)
- Shining in the Darkness (MD)
- Shining Resonance Refrain (Switch)
- Shinobi (VC Arcade)
- Shinobi (3DS)
- Shinobi (GG)
- Shinobi III: Return of the Ninja Master (MD)
- Shiny The Firefly (Wii U eShop)
- Shio (Switch eShop)
- SHiRO 011 (Switch eShop)
- Shock Troopers (Neo Geo)
- Shock Troopers 2nd Squad (Neo Geo)
- Shockman (TG-16)
- Shodai Nekketsu Kōha Kunio-kun (SNES)
- SHOOT THE BALL (3DS eShop)
- SHOOT THE BALL (Wii U eShop)
- Shootanto: Evolutionary Mayhem (WiiWare)
- Shooting Range by Thornbury Software (Wii U eShop)
- SHOOTY SPACE (Wii U eShop)
- Shovel Knight (Wii U eShop)
- Shovel Knight (3DS eShop)
- Shovel Knight (Wii U)
- Shovel Knight Showdown (Switch eShop)
- Shovel Knight: King Of Cards (Switch eShop)
- Shovel Knight: Specter of Torment (Switch eShop)
- Shovel Knight: Treasure Trove (Switch eShop)
- Shu (Switch eShop)
- Shut Eye (Switch eShop)
- SHUT THE BOX (Wii U eShop)
- Shuttle Rush (Wii U eShop)
- Sid Meier's Civilization VI (Switch)
- Sid Meier's Pirates! (Wii)
- Side Pocket (GB)
- Siegecraft Commander (Switch eShop)
- Siesta Fiesta (3DS eShop)
- Sigi - A Fart for Melusina (Switch eShop)
- Sigma Star Saga (GBA)
- Silent Debuggers (TG-16)
- Silent Hill Play Novel (GBA)
- Silent Hill: Shattered Memories (Wii)
- Silver Chains (Switch eShop)
- Silver Star Chess (WiiWare)
- Silver Star Chess (Switch eShop)
- Silver Star Reversi (WiiWare)
- Sim City Creator (DS)
- Sim City DS (DS)
- SimAnimals (Wii)
- SimCity (SNES)
- SimCity Creator (Wii)
- SimCity DS (DS)
- SimEarth: The Living Planet (TG-16)
- Simply Mahjong (DSiWare)
- Simply Minesweeper (DSiWare)
- Simply Solitaire (DSiWare)
- Simply Sudoku (DSiWare)
- Sin and Punishment (N64)
- Sin and Punishment: Star Successor (Wii)
- Sine Mora EX (Switch)
- SiNG Party (Wii U)
- Sinister Assistant (Wii U eShop)
- Sinner: Sacrifice for Redemption (Switch eShop)
- Six Miles Under (Wii U eShop)
- Six Sides of the World (Wii U eShop)
- Six Sides of the World (Switch eShop)
- Skate It (Wii)
- Skate It (DS)
- Skate or Die! (NES)
- Skater Cat (3DS eShop)
- SKEASY (Wii U eShop)
- Skee-Ball (Switch eShop)
- Skellboy (Switch eShop)
- Sketch Wars (Wii U eShop)
- Skies of Arcadia Legends (GCN)
- Skies Of Fury DX (Switch eShop)
- SKORB (Wii U eShop)
- Skullgirls 2nd Encore (Switch eShop)
- Skunky B's Super Slots Saga #1 (Wii U eShop)
- Sky Crawlers: Innocent Aces (Wii)
- Sky Force Anniversary (Wii U eShop)
- Sky Force Anniversary (Switch eShop)
- Sky Force Reloaded (Switch eShop)
- Sky Gamblers: Storm Raiders (Switch eShop)
- Sky Kid (NES)
- Sky Ride (Switch eShop)
- Sky Rogue (Switch eShop)
- Skylanders Giants (Wii)
- Skylanders Giants (Wii U)
- Skylanders Giants (3DS)
- Skylanders Imaginators (Wii U)
- Skylanders Imaginators (Switch)
- Skylanders SuperChargers (Wii U)
- Skylanders SuperChargers Racing (3DS)
- Skylanders SuperChargers Racing (Wii)
- Skylanders SWAP Force (Wii U)
- Skylanders SWAP Force (3DS)
- Skylanders Trap Team (Wii U)
- Skylanders Trap Team (Wii)
- Skylanders Trap Team (3DS)
- Skylanders: Spyro's Adventure (3DS)
- Skylanders: Spyro's Adventure (Wii)
- SKYPEACE (3DS eShop)
- Skypeace (Switch eShop)
- SkyScrappers (Switch eShop)
- SkyTime (Switch eShop)
- Slain! (Wii U eShop)
- Slain: Back From Hell (Switch eShop)
- Slam Land (Switch eShop)
- Slay the Spire (Switch eShop)
- Slayaway Camp: Butcher's Cut (Switch eShop)
- Sled Shred (Wii)
- Sleep Clock: Record and Analyse Your Sleep Patterns (DSiWare)
- Sleep Tight (Switch eShop)
- Slender: The Arrival (Wii U eShop)
- Slice It! (3DS eShop)
- Slice, Dice & Rice (Switch eShop)
- Slime-san (Switch eShop)
- Sling Ming (Switch eShop)
- Slingo Quest (DSiWare)
- Slingo Supreme (DSiWare)
- Slitherlink by Nikoli (3DS eShop)
- Slots - Pharaoh's Riches (Wii U eShop)
- SMART Adventures Mission Math: Sabotage at the Space Station (Wii U eShop)
- Smart Girl's Playhouse Mini (DSiWare)
- Smarty Pants (Wii)
- Smash Bowling 3D (3DS eShop)
- Smash Cat Heroes (3DS eShop)
- Smash Table Tennis (NES)
- SmileBASIC (3DS eShop)
- SmileBASIC for Wii U (Wii U eShop)
- SMITE (Switch eShop)
- Smoke And Sacrifice (Switch eShop)
- Smurfs 2 (DS)
- Snail Mail (WiiWare)
- Snake Den (Wii U eShop)
- Snake Pass (Switch eShop)
- Snake Rattle 'n' Roll (NES)
- Snake vs Snake (Switch eShop)
- Snakenoid (DSiWare)
- Snakenoid Deluxe (DSiWare)
- Snapdots (DSiWare)
- Sneaky Ninja (Wii U eShop)
- Sneezies (WiiWare)
- Sniper Elite V2 (Wii U)
- Snipperclips - Cut it out, together! (Switch eShop)
- Snipperclips Plus: Cut it out, together! (Switch)
- SNK 40th Anniversary Collection (Switch)
- SNK Arcade Classics Vol. 1 (Wii)
- SNK Heroines: Tag Team Frenzy (Switch)
- SNK Vs Capcom Card Fighters DS (DS)
- Snooker 19 (Switch)
- Snow Moto Racing 3D (3DS eShop)
- Snow Moto Racing Freedom (Switch)
- Snowball (Wii U eShop)
- Snowboard Kids (N64)
- Snowboard Riot (WiiWare)
- Snowboard Xtreme (DSiWare)
- Snowpack Park (WiiWare)
- Soap Dodgem (Switch eShop)
- Soccer (NES)
- Soccer Bashi (WiiWare)
- Soccer Brawl (Neo Geo)
- Soccer Slammers (Switch eShop)
- Soccer Up 3D (3DS eShop)
- Soccer Up! (WiiWare)
- Sokomania (DSiWare)
- Sokomania 2: Cool Job (DSiWare)
- SOL DIVIDE -Sword Of Darkness- (Switch eShop)
- Solar Flux (Switch eShop)
- Solatorobo: Red the Hunter (DS)
- Soldam: Drop, Connect, Erase (Switch)
- Soldier Blade (TG-16)
- Solitaire (WiiWare)
- Solitaire (Wii U eShop)
- Solitaire (Switch eShop)
- Solitaire Battle Royal (Switch eShop)
- Solitaire Dungeon Escape (Wii U eShop)
- Solomon's Key (NES)
- Solomon's Key (VC Arcade)
- Solstice Chronicles: MIA (Switch eShop)
- Son of a Witch (Switch eShop)
- Song Of Memories (Switch)
- Songbringer (Switch eShop)
- Sonic & All-Stars Racing Transformed (3DS)
- Sonic & All-Stars Racing Transformed (Wii U)
- Sonic & Knuckles (MD)
- Sonic & SEGA All-Stars Racing (Wii)
- Sonic & SEGA All-Stars Racing (DS)
- Sonic 3D Blast (MD)
- Sonic Advance (GBA)
- Sonic Advance 3 (GBA)
- Sonic Adventure 2: Battle (GCN)
- Sonic Adventure DX: Director's Cut (GCN)
- Sonic and the Black Knight (Wii)
- Sonic and the Secret Rings (Wii)
- Sonic Blast (GG)
- Sonic Boom: Fire & Ice (3DS)
- Sonic Boom: Rise of Lyric (Wii U)
- Sonic Boom: Shattered Crystal (3DS)
- Sonic Chaos (SMS)
- Sonic Chronicles: The Dark Brotherhood (DS)
- Sonic Classic Collection (DS)
- Sonic Colours (Wii)
- Sonic Colours (DS)
- Sonic Drift 2 (GG)
- Sonic Forces (Switch)
- Sonic Gems Collection (GCN)
- Sonic Generations (3DS)
- Sonic Heroes (GCN)
- Sonic Labyrinth (GG)
- Sonic Lost World (Wii U)
- Sonic Lost World (3DS)
- Sonic Mania (Switch eShop)
- Sonic Mania Plus (Switch)
- Sonic Mega Collection (GCN)
- Sonic Riders: Zero Gravity (Wii)
- Sonic Rush (DS)
- Sonic Rush Adventure (DS)
- Sonic Spinball (MD)
- Sonic the Hedgehog (MD)
- Sonic the Hedgehog (SMS)
- Sonic the Hedgehog (GG)
- Sonic the Hedgehog 2 (MD)
- Sonic the Hedgehog 2 (SMS)
- Sonic the Hedgehog 2 (GG)
- Sonic the Hedgehog 3 (MD)
- Sonic the Hedgehog 4: Episode 1 (WiiWare)
- Sonic the Hedgehog: Triple Trouble (GG)
- Sonic Unleashed (Wii)
- SonSon (VC Arcade)
- Soon Shine (Wii U eShop)
- Soratobu Bunbun Baan (Switch eShop)
- Soul Axiom (Wii U eShop)
- Soul Blazer (SNES)
- Soul Bubbles (DS)
- Soul of Darkness (DSiWare)
- Soul Saga: Episode I (Wii U eShop)
- Soulblight (Switch eShop)
- SoulCalibur II (GCN)
- SoulCalibur Legends (Wii)
- Soundfall (Switch eShop)
- South Park (N64)
- South Park: The Fractured But Whole (Switch)
- South Park: The Stick of Truth (Switch eShop)
- Space Ace (DSiWare)
- Space Channel 5: Ulala's Cosmic Attack (GBA)
- Space Chimps (Wii)
- Space Cows (Switch eShop)
- Space Dave! (Wii U eShop)
- Space Dave! (Switch eShop)
- Space Defender Battle Infinity (3DS eShop)
- Space Harrier (SMS)
- Space Harrier (VC Arcade)
- Space Harrier II (MD)
- Space Hulk (Wii U eShop)
- Space Hunted (Wii U eShop)
- Space Invaders Extreme (DS)
- Space Invaders Get Even (WiiWare)
- Space Invaders: The Original Game (SNES)
- Space Invaders: Virtual Collection (VB)
- Space Lift Danger Panic! (3DS eShop)
- Space Manbow (MSX)
- Space Ribbon (Switch eShop)
- Space Squash (VB)
- Space Station Silicon Valley (N64)
- Space Trek (WiiWare)
- Spaceball: Revolution (WiiWare)
- Spaceball: Revolution (DSiWare)
- Spacecats With Lasers (Switch eShop)
- Spacejacked (Switch eShop)
- SpaceRoads (Wii U eShop)
- Sparkle 2 (Switch eShop)
- Sparkle 2 EVO (Switch eShop)
- Sparkle 3 Genesis (Switch eShop)
- Sparkle Snapshots (DSiWare)
- Sparkle Snapshots 3D (3DS eShop)
- Sparkle Unleashed (Switch eShop)
- Sparkle ZERO (Switch eShop)
- Spartan (Switch eShop)
- Spectrobes (DS)
- Spectrum (Switch eShop)
- Speed Brawl (Switch eShop)
- SpeedThru: Potzol's Puzzle (3DS eShop)
- SpeedX 3D (3DS eShop)
- SpeedX 3D Hyper Edition (3DS eShop)
- Spellcaster's Assistant (Wii U eShop)
- Spellspire (Switch eShop)
- Spelunker (NES)
- Spelunker Party! (Switch eShop)
- Spencer (Switch eShop)
- SPHERE SLICE (Wii U eShop)
- SphereZor (Wii U eShop)
- Spheroids (Wii U eShop)
- Spheroids (Switch eShop)
- Sphinx and the Cursed Mummy (Switch)
- Spider Solitaire F (Switch eShop)
- Spider-Man 2 (DS)
- Spider-Man 3 (Wii)
- Spider-Man 3 (DS)
- Spider-Man and Venom: Maximum Carnage (SNES)
- Spider-Man: Battle For New York (DS)
- Spider-Man: Edge of Time (3DS)
- Spider-Man: Edge of Time (Wii)
- Spider-Man: Friend Or Foe (DS)
- Spider-Man: Shattered Dimensions (Wii)
- Spider-Man: Web of Shadows (Wii)
- SpiderSolitaire BLACK (Switch eShop)
- SPIKEY WALLS (Wii U eShop)
- Spin Six (DSiWare)
- Spin the Bottle: Bumpie's Party (Wii U eShop)
- Spinmaster (Neo Geo)
- Spintires: MudRunner - American Wilds Edition (Switch)
- Spiral Splatter (Switch eShop)
- Spirit Camera: The Cursed Memoir (3DS)
- Spirit Hunters Inc. Shadow/Light (DSiWare)
- SpiritSphere DX (Switch eShop)
- Splash Blast Panic (Switch eShop)
- Splash or Crash (3DS eShop)
- Splasher (Switch eShop)
- SPLASHY DUCK (Wii U eShop)
- Splat the Difference (3DS eShop)
- Splat The Fruit (Switch eShop)
- Splatoon (Wii U)
- Splatoon 2 (Switch)
- Splatoon 2: Octo Expansion (Switch eShop)
- Splatterhouse (TG-16)
- Splatterhouse 2 (MD)
- Splitter Critters (Switch eShop)
- SPOGS Racing (WiiWare)
- SpongeBob HeroPants (3DS)
- SpongeBob SquarePants: Creature from the Krusty Krab (Wii)
- SpongeBob Squarepants: Plankton's Robotic Revenge (Wii U)
- SpongeBob SquarePants: Plankton's Robotic Revenge (3DS)
- SpongeBob SquigglePants (Wii)
- SpongeBob SquigglePants 3D (3DS)
- Spore (DS)
- Spore Hero (Wii)
- Spore Hero Arena (DS)
- Sports Party (Wii)
- Sports Party (Switch)
- Sportsball (Wii U eShop)
- Spot It! Challenge (DSiWare)
- Spot It! Mean Machines (DSiWare)
- Spot the Difference (DSiWare)
- Spot The Difference (Switch eShop)
- Spot the Differences! (WiiWare)
- Spot the Differences! (3DS eShop)
- Spot the Differences: Party! (Wii U eShop)
- Spotto! (DSiWare)
- Spy Chameleon (Wii U eShop)
- Spy Chameleon (Switch eShop)
- Spy Hunter (3DS)
- Spyborgs (Wii)
- Squareboy vs Bullies: Arena Edition (Switch eShop)
- Squids Odyssey (Wii U eShop)
- Squids Odyssey (3DS eShop)
- Squids Odyssey (Switch eShop)
- Sssnakes (3DS eShop)
- SSX 3 (GCN)
- SSX Blur (Wii)
- SSX On Tour (GCN)
- SSX Tricky (GCN)
- Stack 'em High (New 3DS)
- Stack-Up (NES)
- Stakes Winner (Neo Geo)
- Stakes Winner 2 (Neo Geo)
- Star Force (VC Arcade)
- Star Fox (SNES)
- Star Fox 2 (SNES)
- Star Fox 64 (N64)
- Star Fox 64 3D (3DS)
- Star Fox Adventures (GCN)
- Star Fox Command (DS)
- Star Fox Guard (Wii U eShop)
- Star Fox Guard (Wii U)
- Star Fox Zero (Wii U)
- Star Fox: Assault (GCN)
- Star Ghost (Wii U eShop)
- Star Ghost (Switch eShop)
- Star Ocean (SNES)
- Star Parodier (TG-16)
- Star Sky (Wii U eShop)
- Star Sky 2 (Wii U eShop)
- Star Soldier (NES)
- Star Soldier R (WiiWare)
- Star Splash: Shattered Star (Wii U eShop)
- Star Story: The Horizon Escape (Switch eShop)
- Star Trek: Conquest (Wii)
- Star Trek: Starfleet Academy Starship Bridge Simulator (SNES)
- Star Trek: Tactical Assault (DS)
- Star Wars Episode I: Battle for Naboo (N64)
- Star Wars Episode I: Racer (N64)
- Star Wars Pinball (Wii U eShop)
- Star Wars Pinball (3DS eShop)
- Star Wars Rogue Squadron II: Rogue Leader (GCN)
- Star Wars Rogue Squadron III: Rebel Strike (GCN)
- Star Wars The Clone Wars: Lightsaber Duels (Wii)
- Star Wars: Flight of the Falcon (GBA)
- Star Wars: Lethal Alliance (DS)
- Star Wars: Rogue Squadron (N64)
- Star Wars: Shadows of the Empire (N64)
- Star Wars: The Force Unleashed (Wii)
- Star Wars: The Force Unleashed II (Wii)
- Starbeast (Wii U eShop)
- Stardew Valley (Wii U eShop)
- Stardew Valley (Switch eShop)
- Stardust Amazoness (3DS)
- Stardust Galaxy Warriors: Stellar Climax (Switch eShop)
- Starlink: Battle for Atlas (Switch)
- Starman (Switch eShop)
- Starship Avenger Operation: Take Back Earth (Switch eShop)
- Starship Patrol (DSiWare)
- Startide (Switch eShop)
- StarTropics (NES)
- STARWHAL (Wii U eShop)
- State of Anarchy: Master of Mayhem (Switch eShop)
- State of Mind (Switch)
- STAY (Switch eShop)
- Steal Princess (DS)
- Stealth Inc 2: A Game of Clones (Wii U eShop)
- Steamburg (Switch eShop)
- SteamWorld Dig (3DS eShop)
- SteamWorld Dig (Wii U eShop)
- SteamWorld Dig (Switch eShop)
- SteamWorld Dig 2 (3DS eShop)
- SteamWorld Dig 2 (Switch eShop)
- SteamWorld Heist (3DS eShop)
- SteamWorld Heist (Wii U eShop)
- SteamWorld Heist: Ultimate Edition (Switch eShop)
- SteamWorld: Tower Defense (DSiWare)
- SteanWorld Dig 2 (3DS eShop)
- Steel Diver (3DS)
- Steel Diver: Sub Wars (3DS eShop)
- Steel Empire (3DS eShop)
- STEEL LORDS (Wii U eShop)
- Steel Rivals (Wii U eShop)
- Steep (Switch)
- Steins;Gate Elite (Switch)
- Stella Glow (3DS)
- Step Up! (WiiWare)
- Steredenn: Binary Stars (Switch eShop)
- Stern Pinball Arcade (Switch)
- Steven Universe: Save the Light (Switch eShop)
- Stick It To The Man (Wii U eShop)
- Stick It to The Man (Switch eShop)
- Stickman Super Athletics (3DS eShop)
- Stikbold! A Dodgeball Adventure Deluxe (Switch eShop)
- Stinger (NES)
- Stone Shire (Wii U eShop)
- Stonekeep: Bones of the Ancestors (WiiWare)
- Stop Stress: A Day of Fury (WiiWare)
- Storm Boy (Switch eShop)
- Storm Chaser - Tornado Alley (New 3DS)
- Storm In A Teacup (Switch eShop)
- Story of Seasons (3DS)
- Story of Seasons (Tentative Title) (Switch eShop)
- Story of Seasons: Trio of Towns (3DS)
- Stratego: Next Edition (DSiWare)
- Street Fighter 2010: The Final Fight (NES)
- Street Fighter 30th Anniversary Collection (Switch)
- Street Fighter Alpha 2 (SNES)
- Street Fighter Alpha 3 (GBA)
- Street Fighter Alpha: Warriors' Dreams (GBC)
- Street Fighter II' Turbo: Hyper Fighting (SNES)
- Street Fighter II': Champion Edition (TG-16)
- Street Fighter II': Special Champion Edition (MD)
- Street Fighter II: The World Warrior (SNES)
- Street Heat (Switch eShop)
- Street Hoop (Neo Geo)
- Street Racer (SNES)
- Streets of Rage (MD)
- Streets of Rage 2 (MD)
- Streets of Rage 3 (MD)
- Streets of Red - Devil's Dare Deluxe (Switch eShop)
- Streets of Rogue (Switch eShop)
- Strider (MD)
- Strike Force Foxx (3DS eShop)
- Strikers 1945 (Switch eShop)
- Strikers 1945 II (Switch eShop)
- Strikers 1945 Plus (Neo Geo)
- Strong Bad Episode 1 - Homestar Ruiner (WiiWare)
- Strong Bad Episode 2 - Strong Badia the Free (WiiWare)
- Strong Bad Episode 3 - Baddest of the Bands (WiiWare)
- Strong Bad Episode 4 - Dangeresque 3: The Criminal Projective (WiiWare)
- Strong Bad Episode 5 - 8-Bit is Enough (WiiWare)
- Stump (Switch eShop)
- Stunt Cars (WiiWare)
- Stunt Race FX (SNES)
- sU and the Quest for meaning (Switch eShop)
- SubaraCity (3DS eShop)
- SubaraCity (Switch eShop)
- Subdivision Infinity DX (Switch eShop)
- Sublevel Zero Redux (Switch eShop)
- Subscribe & Punch! (Switch eShop)
- Subsurface Circular (Switch eShop)
- Successfully Learning English: Year 2 (WiiWare)
- Successfully Learning English: Year 2 (DSiWare)
- Successfully Learning English: Year 3 (DSiWare)
- Successfully Learning English: Year 3 (WiiWare)
- Successfully Learning English: Year 4 (DSiWare)
- Successfully Learning English: Year 4 (WiiWare)
- Successfully Learning English: Year 5 (DSiWare)
- Successfully Learning English: Year 5 (WiiWare)
- Successfully Learning German: Year 2 (DSiWare)
- Successfully Learning German: Year 2 (WiiWare)
- Successfully Learning German: Year 3 (WiiWare)
- Successfully Learning German: Year 3 (DSiWare)
- Successfully Learning German: Year 4 (WiiWare)
- Successfully Learning German: Year 4 (DSiWare)
- Successfully Learning German: Year 5 (DSiWare)
- Successfully Learning German: Year 5 (WiiWare)
- Successfully Learning Mathematics: Year 2 (WiiWare)
- Successfully Learning Mathematics: Year 2 (DSiWare)
- Successfully Learning Mathematics: Year 3 (DSiWare)
- Successfully Learning Mathematics: Year 3 (WiiWare)
- Successfully Learning Mathematics: Year 4 (WiiWare)
- Successfully Learning Mathematics: Year 4 (DSiWare)
- Successfully Learning Mathematics: Year 5 (WiiWare)
- Successfully Learning Mathematics: Year 5 (DSiWare)
- Sudoku (DSiWare)
- Sudoku 150! For Challengers (DSiWare)
- Sudoku 4Pockets (DSiWare)
- Sudoku 50! For Beginners (DSiWare)
- Sudoku and Permudoku (Wii U eShop)
- Sudoku by Nikoli (3DS eShop)
- Sudoku Challenge! (WiiWare)
- Sudoku Challenge! (DSiWare)
- Sudoku Gridmaster (DS)
- Sudoku Party (3DS eShop)
- Sudoku Party (Wii U eShop)
- Sudoku Sensei (DSiWare)
- Suicide Guy (Switch eShop)
- Suicide Guy: Sleepin' Deeply (Switch eShop)
- Suikoden: Tierkreis (DS)
- Sujin Taisen Number Battles (DSiWare)
- Sumer (Switch eShop)
- Sumico (3DS eShop)
- Summer Athletics (Wii)
- Summer Athletics 2009 (Wii)
- Summer Carnival '92 RECCA (NES)
- Summer Games II (C64)
- Sundered: Eldritch Edition (Switch eShop)
- Sunset Riders (SNES)
- Sunu Ikkibu: Din Nahu (Switch eShop)
- Super Adventure Island (SNES)
- Super Adventure Island II (SNES)
- Super Air Zonk: Rockabilly Paradise (TG-16)
- Super Beat Sports (Switch eShop)
- Super Black Bass 3D (3DS)
- Super Blackjack Battle 2 Turbo Edition - The Card Warriors (Switch eShop)
- Super Bomberman (SNES)
- Super Bomberman R (Switch)
- Super Bonk (SNES)
- Super Bonk 2 (SNES)
- Super Boss Gaiden (SNES)
- Super C (NES)
- Super Cane Magic ZERO (Switch eShop)
- Super Castlevania IV (SNES)
- Super Chariot (Switch)
- Super Crush K.O. (Switch eShop)
- Super Daryl Deluxe (Switch eShop)
- Super Destronaut (Wii U eShop)
- Super Destronaut 2: Go Duck Yourself (Wii U eShop)
- Super Destronaut 3D (New 3DS)
- Super Destronaut DX (Switch eShop)
- Super Dodge Ball (NES)
- Super Dodge Ball Advance (GBA)
- Super Dodgeball Brawlers (DS)
- Super Doomed'n Damned (Wii U eShop)
- Super Double Dragon (SNES)
- Super Dragon Ball Heroes: World Mission (Switch)
- Super Dungeon Tactics (Switch eShop)
- Super E.D.F. Earth Defense Force (SNES)
- Super Empire Strikes Back (SNES)
- Super Fantasy Zone (MD)
- Super Ghouls 'n Ghosts (SNES)
- Super Ghouls 'n Ghosts (GBA)
- Super Glove Ball (NES)
- Super Hang-On (VC Arcade)
- Super Hero Math (Wii U eShop)
- Super Hydorah (Switch eShop)
- Super Hyperactive Ninja (Switch eShop)
- Super Inefficient Golf (Switch eShop)
- Super Little Acorns 3D Turbo (3DS eShop)
- Super Mario 3D Land (3DS)
- Super Mario 3D World (Wii U)
- Super Mario 64 (N64)
- Super Mario 64 DS (DS)
- Super Mario Advance (GBA)
- Super Mario Advance 2: Super Mario World (GBA)
- Super Mario Advance 3: Yoshi's Island (GBA)
- Super Mario Advance 4: Super Mario Bros. 3 (GBA)
- Super Mario All-Stars (SNES)
- Super Mario All-Stars 25th Anniversary Edition (Wii)
- Super Mario Ball (GBA)
- Super Mario Bros. (NES)
- Super Mario Bros. 2 (NES)
- Super Mario Bros. 3 (NES)
- Super Mario Bros. Deluxe (GBC)
- Super Mario Bros.: The Lost Levels (NES)
- Super Mario Galaxy (Wii)
- Super Mario Galaxy 2 (Wii)
- Super Mario Kart (SNES)
- Super Mario Land (GB)
- Super Mario Land 2: 6 Golden Coins (GB)
- Super Mario Maker (Wii U)
- Super Mario Maker for Nintendo 3DS (3DS)
- Super Mario Odyssey (Switch)
- Super Mario Party (Switch)
- Super Mario RPG: Legend of the Seven Stars (SNES)
- Super Mario Run (Mobile)
- Super Mario Sunshine (GCN)
- Super Mario World (SNES)
- Super Mario World 2: Yoshi's Island (SNES)
- Super Meat Boy (Wii U eShop)
- Super Meat Boy (Switch eShop)
- Super Meat Boy Forever (Switch eShop)
- Super Metroid (SNES)
- Super Mighty Power Man (Switch eShop)
- Super Monkey Ball (GCN)
- Super Monkey Ball 2 (GCN)
- Super Monkey Ball 3D (3DS)
- Super Monkey Ball Adventure (GCN)
- Super Monkey Ball Step & Roll (Wii)
- Super Monkey Ball Touch and Roll (DS)
- Super Monkey Ball: Banana Blitz (Wii)
- Super Nazo Puyo Tsuu: Rulue no Tetsuwan Hanjyouki (SNES)
- Super Nazo Puyo: Rulue no Roux (SNES)
- Super Neptunia RPG (Switch)
- Super One More Jump (Switch eShop)
- Super Pang (SNES)
- Super Paper Mario (Wii)
- Super Ping Pong Trick Shot (Switch eShop)
- Super Princess Peach (DS)
- Super Punch-Out!! (SNES)
- Super Putty (SNES)
- Super Putty Squad (Switch)
- Super Puyo Puyo (SNES)
- Super Puyo Puyo 2: Tsuu (SNES)
- Super Puyo Puyo 2: Tsuu Remix (SNES)
- Super R-Type (SNES)
- Super Return of the Jedi (SNES)
- SUPER ROBO MOUSE (Wii U eShop)
- Super Robot Taisen OG Saga: Endless Frontier (DS)
- Super Robot Wars T (Switch)
- Super Robot Wars UX (3DS)
- Super Rock Blasters! (Switch eShop)
- Super Rocket Shootout (Switch eShop)
- Super Saurio Fly (Switch eShop)
- Super Scribblenauts (DS)
- Super Sidekicks (Neo Geo)
- Super Sidekicks 2: The World Championship (Neo Geo)
- SUPER SIDEKICKS 3: THE NEXT GLORY (Neo Geo)
- Super Smash Bros. (N64)
- Super Smash Bros. Brawl (Wii)
- Super Smash Bros. for Nintendo 3DS (3DS)
- Super Smash Bros. for Wii U (Wii U)
- Super Smash Bros. Melee (GCN)
- Super Smash Bros. Ultimate (Switch)
- Super Sportmatchen (Switch eShop)
- Super Star Soldier (TG-16)
- Super Star Wars (SNES)
- Super Street Fighter II (MD)
- Super Street Fighter II: The New Challengers (SNES)
- Super Street Fighter II: Turbo Revival (GBA)
- Super Street Fighter IV 3D Edition (3DS)
- Super Strike Beach Volleyball (3DS eShop)
- Super Swap (DSiWare)
- Super Swing Golf PANGYA (Wii)
- Super Swing Golf: Season 2 (Wii)
- Super Tennis (SNES)
- Super Thunder Blade (MD)
- Super Toy Cars (Wii U eShop)
- Super Toy Cars (Switch eShop)
- Super Treasure Arena (Switch eShop)
- Super Turrican (SNES)
- Super Turrican 2 (SNES)
- Super Ubie Land (Wii U eShop)
- Super Ultra Star Shooter (Wii U eShop)
- Super Volley Blast (Switch eShop)
- Super Yum Yum: Puzzle Adventures (DSiWare)
- Superbeat: Xonic (Switch)
- Superbrothers: Sword & Sworcery EP (Switch eShop)
- Superman Returns (DS)
- Superman: The New Adventures (N64)
- Supermarket Mania (DSiWare)
- Superola and the Lost Burgers (Switch eShop)
- Surf's Up (Wii)
- Surfacer+ (DSiWare)
- Surfin' Sam - Attack of the Aqualites (Wii U eShop)
- Surgeon Simulator CPR (Switch eShop)
- Survive! Mr.Cube (Switch eShop)
- Surviving High School (DSiWare)
- Survivor - Heroes (3DS)
- Sushi Striker: The Way of Sushido (3DS)
- Sushi Striker: The Way of Sushido (Switch)
- Suspension Railroad Simulator (Wii U eShop)
- Sutte Hakkun (SNES)
- Swamp Defense 2 (Switch eShop)
- SWAP BLOCKS (Wii U eShop)
- Swap Fire (Wii U eShop)
- Swap This! (Switch eShop)
- Swapdoodle (3DS eShop)
- Sweet Home (NES)
- Sweet Memories Blackjack (3DS eShop)
- Sweetest Thing (Wii U eShop)
- Swim Out (Switch eShop)
- SWIPE (New 3DS)
- Sword of the Guardian (Switch eShop)
- Sword of Vermilion (MD)
- Swords & Darkness (3DS eShop)
- Swords & Soldiers (WiiWare)
- Swords & Soldiers (Wii U eShop)
- Swords & Soldiers 3D (3DS eShop)
- Swords & Soldiers II (Wii U eShop)
- Swords & Soldiers II Shawarmageddon (Switch eShop)
- Syberia (Switch)
- Syberia 1 & 2 (Switch)
- Syberia 2 (Switch)
- Syberia 3 (Switch)
- Sydney Hunter and the Curse of the Mayan (Switch eShop)
- Symphony of Eternity (3DS eShop)
- Synaptic Drive (Switch)
- Sync (Wii U eShop)
- System Flaw Recruit (DSiWare)