- Zaccaria Pinball (Switch eShop)
- ZaciSa's Last Stand (Wii U eShop)
- ZaciSa: Defense of the Crayon Dimensions! (Wii U eShop)
- Zack & Wiki: Quest for Barbaros' Treasure (Wii)
- Zanac (NES)
- Zarvot (Switch eShop)
- Zaxxon (VC Arcade)
- Zed Blade (Neo Geo)
- Zelda II: The Adventure of Link (NES)
- Zen Bound 2 (Switch eShop)
- Zen Pinball 2 (Wii U eShop)
- Zen Pinball 3D (3DS eShop)
- Zen: Intergalactic Ninja (GB)
- Zenonia (DSiWare)
- Zenquaria: Virtual Aquarium (WiiWare)
- Zenses: Ocean (DS)
- Zenses: Rainforest (DS)
- Zero Escape Volume 3 (3DS)
- Zero Escape: Virtue's Last Reward (3DS)
- Zero Gunner 2 (Switch eShop)
- Zero Time Dilemma (3DS)
- Zeus Quest Remastered (New 3DS)
- Zeus Quest Remastered (Switch eShop)
- Zeus Quests Remastered Anagenissis of Gaia (3DS eShop)
- Zig Zag Go (3DS eShop)
- Ziggurat (Wii U eShop)
- Zimo: Mahjong Fanatic (DSiWare)
- Zoda's Revenge: StarTropics II (NES)
- Zombeer (Wii U eShop)
- Zombie Blaster (DSiWare)
- Zombie Brigade: No Brain No Gain (Wii U eShop)
- Zombie Defense (Wii U eShop)
- Zombie Gold Rush (Switch eShop)
- Zombie Incident (3DS eShop)
- Zombie Night Terror (Switch eShop)
- Zombie Panic in Wonderland (WiiWare)
- Zombie Panic in Wonderland DX (3DS eShop)
- Zombie Panic in Wonderland DX (Switch eShop)
- Zombie Scrapper (Switch eShop)
- Zombie Skape (DSiWare)
- Zombie Slayer Diox (3DS eShop)
- Zombie Vikings (Wii U eShop)
- Zombie Vikings (Switch eShop)
- Zombies Ate My Neighbors (SNES)
- Zombii Attack (WiiWare)
- Zombillie (Switch eShop)
- ZombiU (Wii U)
- Zoo Disc Golf (WiiWare)
- Zoo Frenzy (DSiWare)
- Zoo Hospital (DS)
- Zoo Hospital (Wii)
- Zoo Keeper (DS)
- Zoo Match (Wii U eShop)
- Zoo Resort 3D (3DS)
- Zool: Ninja of the 'Nth' Dimension (GB)
- Zoonies - Escape from Makatu (DSiWare)
- Zoop (GB)
- Zotrix: Solar Division (Switch eShop)
- Zubo (DS)
- Zuma's Revenge (DSiWare)
- Zumba Fitness 2 (Wii)
- Zumba Fitness World Party (Wii)
- Zumba Fitness: World Party (Wii U)
- Zupapa! (Neo Geo)