- Zac to Ombra: Maboroshi no Yuuenchi (DS)
- Zaccaria Pinball (Switch eShop)
- ZaciSa's Last Stand (Wii U eShop)
- ZaciSa: Defense of the Crayon Dimensions! (Wii U eShop)
- Zack & Wiki: Quest for Barbaros' Treasure (Wii)
- Zaidan Houjin Nippon Kanji Nouryoku Kentei Kounin: KanKen DS (DS)
- Zanac (NES)
- Zapper: One Wicked Cricket (GCN)
- ZARA the Fastest Fairy (New 3DS)
- ZARA the Fastest Fairy (Switch eShop)
- Zarvot (Switch eShop)
- Zatch Bell! Mamodo Battles (GCN)
- Zatch Bell! Mamodo Fury (GCN)
- Zaxxon (VC Arcade)
- Zed Blade (Neo Geo)
- Zelda II: The Adventure of Link (NES)
- Zen Bound 2 (Switch eShop)
- Zen Chess Collection (Switch eShop)
- Zen Pinball 2 (Wii U eShop)
- Zen Pinball 3D (3DS eShop)
- Zen: Intergalactic Ninja (GB)
- Zendoku (DS)
- Zenith (Switch eShop)
- Zenmai Zamurai (DS)
- Zenonia (DSiWare)
- Zenquaria: Virtual Aquarium (WiiWare)
- Zenses: Ocean (DS)
- Zenses: Rainforest (DS)
- Zero Escape Volume 3 (3DS)
- Zero Escape: Virtue's Last Reward (3DS)
- Zero Gunner 2 (Switch eShop)
- Zero Time Dilemma (3DS)
- Zeroptian Invasion (Switch eShop)
- Zettai Karen Children DS: Dai-4 no Children (DS)
- Zettai Onkan Master (DS)
- Zettai Onkan Otoda Master (DS)
- Zettai Zetsumei Dangerous Jiisan DS: Dangerous Sensation (DS)
- Zeus Quest Remastered (New 3DS)
- Zeus Quest Remastered (Switch eShop)
- Zeus Quests Remastered Anagenissis of Gaia (3DS eShop)
- Zhu Zhu Babies (DS)
- Zhu Zhu Pets (DS)
- Zhu Zhu Pets 2 (DS)
- Zhu Zhu Pets: Kung Zhu (DS)
- Zhu Zhu Pets: Quest for Zhu (DS)
- Zhu Zhu Princess: Carriages & Castles (DS)
- Zhu Zhu Puppies (DS)
- Zig Zag Go (3DS eShop)
- Ziggurat (Switch eShop)
- Ziggurat (Wii U eShop)
- ZikSquare (Switch eShop)
- Zimo: Mahjong Fanatic (DSiWare)
- Zoda's Revenge: StarTropics II (NES)
- Zoey 101: Field Trip Fiasco (DS)
- Zoids Battle Colosseum (DS)
- Zoids Dash (DS)
- Zoids Saga DS: Legend of Arcadia (DS)
- Zoids Vs. (GCN)
- Zoids Vs. III (GCN)
- Zoids: Battle Legends (GCN)
- Zoids: Full Metal Crash (GCN)
- ZOMB (Switch eShop)
- Zombeer (Wii U eShop)
- Zombie Blaster (DSiWare)
- Zombie Brigade: No Brain No Gain (Wii U eShop)
- Zombie Defense (Wii U eShop)
- Zombie Driver: Immortal Edition (Switch eShop)
- Zombie Gold Rush (Switch eShop)
- Zombie Incident (3DS eShop)
- Zombie Night Terror (Switch eShop)
- Zombie Panic in Wonderland (WiiWare)
- Zombie Panic in Wonderland DX (3DS eShop)
- Zombie Panic in Wonderland DX (Switch eShop)
- Zombie Scrapper (Switch eShop)
- Zombie Skape (DSiWare)
- Zombie Slayer Diox (3DS eShop)
- Zombie Vikings (Switch eShop)
- Zombie Vikings (Wii U eShop)
- Zombieland: Double Tap - Road Trip (Switch)
- Zombies Ate My Neighbors (SNES)
- Zombii Attack (WiiWare)
- Zombillie (Switch eShop)
- ZombiU (Wii U)
- Zoo Disc Golf (WiiWare)
- Zoo Frenzy (DSiWare)
- Zoo Hospital (DS)
- Zoo Hospital (Wii)
- Zoo Keeper (DS)
- Zoo Match (Wii U eShop)
- Zoo Resort 3D (3DS)
- Zoo Tycoon 2 DS (DS)
- Zoo Tycoon DS (DS)
- Zoo Vet: Endangered Animals (DS)
- Zoobles! Spring to Life! (DS)
- ZooCube (GCN)
- Zool: Ninja of the 'Nth' Dimension (GB)
- Zoonies - Escape from Makatu (DSiWare)
- Zoop (GB)
- Zotrix: Solar Division (Switch eShop)
- Zubo (DS)
- Zuma's Revenge (DSiWare)
- Zuma's Revenge! (DS)
- Zumba Burn it Up! (Switch)
- Zumba Fitness 2 (Wii)
- Zumba Fitness World Party (Wii)
- Zumba Fitness: World Party (Wii U)
- Zupapa! (Neo Geo)