- Y.A.S.G (Wii U eShop)
- Yaga (Switch eShop)
- YAKARI: The Mystery of Four-Seasons (3DS)
- Yakitate!! Japan (DS)
- Yakochu II: Satsujin Koro (N64)
- Yakuman (GB)
- Yakyuu Famista Evolution (Switch eShop)
- Yamaha Supercross (DS)
- Yamakawa Shuppansha Kanshuu: Shousetsu Nihonshi DS (DS)
- Yamakawa Shuppansha Kanshuu: Shousetsu Sekaishi DS (DS)
- Yard Sale Hidden Treasures: Sunnyville (WiiWare)
- Yareba de Kiru! The Micro Step - Gijutsu de Oboeru Eitango (DS)
- Yars' Revenge (GBC)
- Yars: Recharged (Switch eShop)
- Yatagarasu (3DS eShop)
- Yattaman DS 2 (DS)
- Ye OLDE Cribbage Club: A Later Daters Game (Switch eShop)
- Yeah Yeah Beebiss II (Switch eShop)
- Yeah! Fighting Girl (Switch eShop)
- Year Walk (Wii U eShop)
- Yellow Fins (Switch eShop)
- Yes! PreCure 5 (DS)
- Yes! PreCure 5 GoGo! Zenin ShūGo! Dorīmu Fesutibaru (DS)
- Yes, Your Grace (Switch eShop)
- Yesterday Origins (Switch)
- YesterMorrow (Switch eShop)
- Yet Another Zombie Defense HD (Switch eShop)
- Yggdra Union: We'll Never Fight Alone (GBA)
- Yggdra Unison: Seiken Buyuuden (DS)
- YIIK: A Postmodern RPG (Switch eShop)
- YIIK: A Postmodern RPG (Wii U eShop)
- Yo! Noid (NES)
- Yo-kai Sangokushi (3DS)
- Yo-Kai Watch (3DS)
- Yo-kai Watch 2: Bony Spirits & Fleshy Souls (3DS)
- Yo-kai Watch 2: Psychic Specters (3DS)
- Yo-Kai Watch 3 (3DS)
- Yo-Kai Watch 4 (Switch)
- Yo-Kai Watch Blasters: Red Cat Corps & White Dog Squad (3DS)
- Yo-Kai Watch Busters (3DS)
- Yo-Kai Watch Busters 2 (3DS)
- Yo-kai Watch Jam - Yo-kai Gakuen Y: Wai-Wai Gakuen Seikatsu (Switch)
- Yo-kai Watch Wibble Wobble (Mobile)
- Yo-Kai Watch World (Mobile)
- Yōdanji (Switch eShop)
- Yoga for Wii (Wii)
- Yoga Master (Switch eShop)
- Yoga Master (Wii U eShop)
- Yogi Bear's Gold Rush (GB)
- Yogi Bear: Great Balloon Blast (GBC)
- Yoko & Yuki: Dr. Rat's Revenge (Switch eShop)
- Yoku's Island Express (Switch eShop)
- Yomawari: Lost in the Dark (Switch)
- Yomawari: The Long Night Collection (Switch)
- Yonder: The Cloud Catcher Chronicles (Switch)
- Yonesawara Hospital (Switch eShop)
- Yono And The Celestial Elephants (Switch eShop)
- Yooka-Laylee (Switch eShop)
- Yooka-Laylee (Wii U eShop)
- Yooka-Laylee and the Impossible Lair (Switch)
- Yoshi (GB)
- Yoshi (NES)
- Yoshi Topsy-Turvy (GBA)
- Yoshi Touch & Go (DS)
- Yoshi's Cookie (GB)
- Yoshi's Cookie (NES)
- Yoshi's Crafted World (Switch)
- Yoshi's Island DS (DS)
- Yoshi's New Island (3DS)
- Yoshi's Safari (SNES)
- Yoshi's Story (N64)
- Yoshi's Woolly World (Wii U)
- Yosumin DS (DS)
- You Died but a Necromancer revived you (Switch eShop)
- You Suck At Parking (Switch)
- You, Me, and the Cubes (WiiWare)
- Youkai Poetry (Switch eShop)
- Youmandriver (Switch eShop)
- Young Justice: Legacy (3DS eShop)
- Young Souls (Switch eShop)
- Your Computer Might Be At Risk (Switch eShop)
- Your Shape Fitness Evolved 2013 (Wii U)
- Your Toy (Switch eShop)
- Youropa (Switch eShop)
- YouTube (Switch eShop)
- Youtubers Life 2 (Switch eShop)
- Youtubers Life: OMG Edition (Switch eShop)
- Ys Book I & II (TG-16)
- Ys IX: Monstrum Nox (Switch)
- Ys Memoire: The Oath in Felghana (Switch)
- Ys Origin (Switch)
- Ys Strategy (DS)
- Ys VIII: Lacrimosa of Dana (Switch)
- Ys X: Nordics (Switch)
- Ys: The Vanished Omens (SMS)
- Yu Yu Hakusho DS: Ankoku Bujutsukai Hen (DS)
- Yu Yu Hakusho Makyō Tōitsusen (MD)
- Yu-Gi-Oh! 5D's Stardust Accelerator: World Championship 2009 (DS)
- Yu-Gi-Oh! 5D's World Championship 2010: Reverse of Arcadia (DS)
- Yu-Gi-Oh! 5D's World Championship 2011: Over the Nexus (DS)
- Yu-Gi-Oh! 5D's: Duel Transer (Wii)
- Yu-Gi-Oh! Dark Duel Stories (GBC)
- Yu-Gi-Oh! Destiny Board Traveler (GBA)
- Yu-Gi-Oh! Duel Monsters 6: Expert 2 (GBA)
- Yu-Gi-Oh! Duel Monsters GX: Card Almanac (DS)
- Yu-Gi-Oh! Duel Monsters GX: Spirit Summoner (DS)
- Yu-Gi-Oh! Duel Monsters: Nightmare Troubadour (DS)
- Yu-Gi-Oh! Duel Monsters: World Championship 2007 (DS)
- Yu-Gi-Oh! Duel Monsters: World Championship 2008 (DS)
- Yu-Gi-Oh! Legacy of the Duelist: Link Evolution (Switch)
- Yu-Gi-Oh! Master Duel (Switch eShop)
- Yu-Gi-Oh! RUSH DUEL: Dawn of the Battle Royale!! (Switch eShop)
- Yu-Gi-Oh! The Eternal Duelist Soul (GBA)
- Yu-Gi-Oh! The Falsebound Kingdom (GCN)
- Yu-Gi-Oh! The Sacred Cards (GBA)
- Yu-Gi-Oh! World Championship Tournament 2004 (GBA)
- Yu-Gi-Oh! Worldwide Edition: Stairway to the Destined Duel (GBA)
- Yu-Gi-Oh! Zexal World Duel Carnival (3DS)
- YU-NO: A Girl Who Chants Love at the Bound of this World (Switch)
- Yukiiro Sign (Switch eShop)
- Yukkuri Tanoshimu Otona no Jigsaw Puzzle DS: Sekai no Meiga 1: Renaissance, Baroque no Kyoshou (DS)
- Yukkuri Tanoshimu Otona no Jigsaw Puzzle DS: Sekai no Meiga 2: Inshou-ha, Kouki Inshou-ha no Kyoshou (DS)
- Yum Yum Cookstar (Switch)
- Yum Yum Line (Switch eShop)
- Yume Koujou Doki Doki Panic (NES)
- Yume Neko DS (DS)
- Yumeiri (Switch eShop)
- Yumemidori Nostalgia (Switch eShop)
- YUMENIKKI -DREAM DIARY- (Switch eShop)
- Yumeutsutsu Re:After (Switch eShop)
- Yumeutsutsu Re:Master (Switch eShop)
- Yumi's Odd Odyssey (3DS eShop)
- Yummy Yummy Cooking Jam (DSiWare)
- Yummy Yummy Cooking Jam (WiiWare)
- Yuoni (Switch eShop)
- Yuppie Psycho: Executive Edition (Switch eShop)
- Yuri (Switch eShop)
- Yurukill: The Calumniation Games (Switch)
- Yuso (Switch eShop)
- Yuuzai x Muzai (DS)