- U Host (Wii U eShop)
- U.N. Squadron (SNES)
- Ubermosh:omega (Switch eShop)
- Ubongo (DSiWare)
- Ubongo (WiiWare)
- Ucchannanchan no Honō no Challenger: Denryū Iraira Bō (N64)
- Uchi no 3 Shimai DS (DS)
- Uchi no 3 Shimai no Karaoke Utagassen (DS)
- UCraft (Wii U eShop)
- uDraw Studio (Wii)
- UEFA Champions League 2004-2005 (GCN)
- UFC Personal Trainer: The Ultimate Fitness System (Wii)
- Ufouria: The Saga (NES)
- UglyDolls: An Imperfect Adventure (Switch eShop)
- Ukkari o Nakusō! Bunshō Yomi Training (DS)
- Ultima: Runes of Virtue (GB)
- Ultima: Runes of Virtue II (GB)
- Ultimate Band (DS)
- Ultimate Card Games (DS)
- Ultimate Chicken Horse (Switch eShop)
- Ultimate Duck Hunting (Wii)
- Ultimate Fighting Championship: Throwdown (GCN)
- Ultimate Fishing Simulator (Switch)
- Ultimate Mortal Kombat (DS)
- Ultimate Muscle: Legends vs. New Generation (GCN)
- Ultimate NES Remix (3DS)
- Ultimate Puzzle Games: Sudoku Edition (DS)
- Ultimate Racing 2D (Switch eShop)
- Ultimate Runner (Switch eShop)
- Ultimate Shooting Collection (Wii)
- Ultimate Spider-Man (DS)
- Ultimate Spider-Man (GCN)
- Ultra Golf (GB)
- Ultra Hyperball (Switch eShop)
- Ultra Off-Road 2019: Alaska (Switch eShop)
- Ultra Space Battle Brawl (Switch eShop)
- Ultra Street Fighter II: The Final Challengers (Switch)
- Ultratron (Wii U eShop)
- Ultrawings (Switch eShop)
- Umihara Kawase Fresh! (Switch)
- Umiuru to Sudoku Shiyo! (DS)
- Un Indien Dans La Ville (GB)
- Unalive (Wii U eShop)
- Unbox: Newbie's Adventure (Switch)
- Uncanny Valley (Switch eShop)
- Unchained Blades (3DS eShop)
- Uncharted Tides: Port Royal (Switch eShop)
- Uncharted Waters: New Horizons (SNES)
- Undead Bowling (3DS eShop)
- Undead Horde (Switch eShop)
- Undead Storm Nightmare (3DS eShop)
- Undead’s Building (Switch eShop)
- Under Night In-Birth Exe:Late[cl-r] (Switch eShop)
- Undercover: Dual Motives (DS)
- Underground (Wii U eShop)
- Underground Pool (DS)
- UnderHero (Switch eShop)
- Undertale (Switch eShop)
- Underwater Attack (DS)
- Underworld Ascendant (Switch eShop)
- Underworld Dreams (Switch eShop)
- Unepic (Switch eShop)
- Unepic (Wii U eShop)
- Unexplored (Switch eShop)
- Unholy Heights (3DS eShop)
- Unholy Heights (Switch eShop)
- Uni (Switch eShop)
- Unicornicopia (Switch eShop)
- Uniracers (SNES)
- Unit 4 (Switch eShop)
- Universal Soldier (GB)
- Universal Studios Theme Parks Adventure (GCN)
- Unknown Fate (Switch eShop)
- Unlucky Mage (3DS eShop)
- UNO (DSiWare)
- UNO (Switch eShop)
- UNO (WiiWare)
- Uno / Skip-Bo / Uno Freefall (DS)
- Uno 52 (DS)
- Unō Kaiten: Match-B? Puzzle DS (DS)
- Unō Kids DS (DS)
- Unō no Tatsujin: Hirameki Kosodate My Angel (DS)
- Unō Tanren UnoTan DS: Shichida Shiki Otona no Shun Kan Training (DS)
- Unravel Two (Switch)
- Unruly Heroes (Switch eShop)
- Unsolved Crimes (DS)
- Untitled Goose Game (Switch eShop)
- Unto The End (Switch eShop)
- Unworthy (Switch eShop)
- UORiS DX (Switch eShop)
- Up (DS)
- Up Up Bot (New 3DS)
- Urban Champion (NES)
- Urban Strike (GB)
- Urban Trial Freestyle (3DS eShop)
- Urban Trial Freestyle 2 (3DS eShop)
- Urban Trial Playground (Switch)
- Urbanix (WiiWare)
- Uridium (C64)
- Urusei Yatsura: Endless Summer (DS)
- USA Today Crossword Challenge (DS)
- USA Today Puzzle Craze (DS)
- Use Your Words (Switch eShop)
- Use Your Words (Wii U eShop)
- Ushiro (Switch eShop)
- UTOPIA 9 - A Volatile Vacation (Switch eShop)
- Utsukushii Nihongo no Kakikata Hanashikata DS (DS)
- Uurnog Uurnlimited (Switch eShop)
- Uwasa no Midori-kun!! Futari no Midori!? (DS)
- Uwasa no Midori-kun!! Natsu Iro Striker (DS)
- uWordsmith (Wii U eShop)