- E.X. Troopers (3DS)
- EA Playground (Wii)
- EA Sports Active (Wii)
- Earth Atlantis (Switch eShop)
- Earth Wars (Switch eShop)
- EarthBound (SNES)
- EarthBound Beginnings (NES)
- Earthlock (Switch eShop)
- Earthlock: Festival of Magic (Wii U eShop)
- Earthworm Jim (MD)
- Earthworm Jim (DSiWare)
- Earthworm Jim 2 (MD)
- Earthworms (Switch eShop)
- Easter Eggztravaganza (DSiWare)
- Eat Beat Deadspike-San (Switch eShop)
- Eat! Fat! FIGHT! (WiiWare)
- Eba & Egg: A Hatch Trip (Wii U eShop)
- Ecco Jr. (MD)
- Ecco The Dolphin (MD)
- Ecco: The Tides of Time (MD)
- Eco Shooter: Plant 530 (WiiWare)
- EctoPlaza (Wii U eShop)
- EDGE (Wii U eShop)
- EDGE (3DS eShop)
- Eduardo the Samurai Toaster (WiiWare)
- Educational Pack of Kids Games (Wii U eShop)
- Eekeemoo - Splinters of the Dark Shard (Switch eShop)
- Egg Mania (GBA)
- EJ Puzzles: Hooked (DSiWare)
- Elebits (Wii)
- Electronic Super Joy (Wii U eShop)
- Electronic Super Joy: Groove City (Wii U eShop)
- Electroplankton (DS)
- Electroplankton Beatnes (DSiWare)
- Electroplankton Hanenbow (DSiWare)
- Electroplankton Lumiloop (DSiWare)
- Electroplankton Luminarrow (DSiWare)
- Electroplankton Marine-Crystals (DSiWare)
- Electroplankton Nanocarp (DSiWare)
- Electroplankton Rec-Rec (DSiWare)
- Electroplankton Sun-Animalcule (DSiWare)
- Electroplankton Trapy (DSiWare)
- Electroplankton Varvoice (DSiWare)
- Eledees: The Adventures of Kai and Zero (DS)
- Element (Switch eShop)
- Elemental Masters (DSiWare)
- Elevator Action (NES)
- Elite Beat Agents (DS)
- Elite Forces: Unit 77 (DSiWare)
- Elliot Quest (Wii U eShop)
- Elliot Quest (3DS eShop)
- Elliot Quest (Switch eShop)
- Elminage Original (3DS eShop)
- Embers of Mirrim (Switch eShop)
- Emergency Heroes (Wii)
- Emergency Room: Real Life Rescues (DS)
- Emojikara: A Clever Emoji Match Game (Wii U eShop)
- Enchanting Mahjong Match (Switch eShop)
- Endless Golf (Wii U eShop)
- Endless Ocean (Wii)
- Endless Ocean 2: Adventures of the Deep (Wii)
- Enduro Racer (SMS)
- Energy Balance (Switch eShop)
- Energy Cycle (Switch eShop)
- Energy Invasion (Switch eShop)
- English Training (DS)
- Enigmatis 2: The Mists of Ravenwood (Switch eShop)
- Enjoy Your Massage! (WiiWare)
- Enter the Gungeon (Switch eShop)
- Epic Dumpster Bear (Wii U eShop)
- Epic Loon (Switch eShop)
- Epic Word Search Collection (3DS eShop)
- Epic Word Search Collection 2 (3DS eShop)
- Epic Word Search Holiday Special (3DS eShop)
- Equestrian Training (DS)
- Equilibrio (WiiWare)
- Equinox (SNES)
- Eragon (DS)
- Escape From Flare Industries (Wii U eShop)
- Escape From Zombie City (3DS eShop)
- Escape Game: Aloha (Switch eShop)
- Escape The Virus: Shoot 'Em Up! (DSiWare)
- Escape the Virus: Swarm Survival (DSiWare)
- Escape Trick: 35 Fateful Enigmas (Switch eShop)
- Escape Trick: Convenience Store (DSiWare)
- Escape Trick: Ninja Castle (DSiWare)
- Escape Trick: The Secret of Rock City Prison (DSiWare)
- Escape! Zombie City (3DS eShop)
- Escapee GO! (DSiWare)
- escapeVektor (3DS eShop)
- escapeVektor: Chapter 1 (WiiWare)
- ESPN Sports Connection (Wii U)
- Essential Sudoku (DS)
- ESWAT: City Under Siege (MD)
- Eternal Champions (MD)
- Eternal Darkness: Sanity's Requiem (GCN)
- Eternal Edge (Switch eShop)
- Eternum Ex (Switch eShop)
- Etherborn (Switch eShop)
- Etrian Mystery Dungeon (3DS)
- Etrian Mystery Dungeon 2 (3DS)
- Etrian Odyssey (DS)
- Etrian Odyssey 2 Untold: The Fafnir Knight (3DS)
- Etrian Odyssey II: Heroes of Lagaard (DS)
- Etrian Odyssey III: The Drowned City (DS)
- Etrian Odyssey IV: Legends of the Titan (3DS)
- Etrian Odyssey Nexus (3DS)
- Etrian Odyssey Untold: The Millennium Girl (3DS)
- Etrian Odyssey V: Beyond the Myth (3DS)
- European Conqueror 3D (3DS eShop)
- European Conqueror X (Switch eShop)
- Evasive Space (WiiWare)
- Ever Oasis (3DS)
- Everspace (Switch eShop)
- Everyday Soccer (DSiWare)
- Evofish (Wii U eShop)
- Ex Oblivione (Wii U eShop)
- Excave (3DS eShop)
- Excave II : Wizard of the Underworld (3DS eShop)
- Excave III : Tower of Destiny (3DS eShop)
- Excite Truck (Wii)
- Excitebike (NES)
- Excitebike 64 (N64)
- Excitebike: World Rally (WiiWare)
- Excitebots: Trick Racing (Wii)
- Exed Exes (VC Arcade)
- Exhaust Heat (SNES)
- Exile's End (Wii U eShop)
- Exit (DS)
- Exorder (Switch eShop)
- Explody Bomb (Wii U eShop)
- Extreme Exorcism (Wii U eShop)
- Extreme Hangman (DSiWare)
- Extreme Hangman 2 (DSiWare)
- EXTREME POKER (Switch eShop)
- Extreme-G (N64)