- E.T. The Extra-Terrestrial and the Cosmic Garden (GBC)
- E.T. The Extra-Terrestrial: Digital Companion (GBC)
- E.T. The Extra-Terrestrial: Escape from Planet Earth (GBC)
- E.X. Troopers (3DS)
- EA Playground (DS)
- EA Playground (Wii)
- EA Sports Active (Wii)
- EA Sports Active 2 Personal Trainer (Wii)
- Eagle Island (Switch eShop)
- EAGLETALON vs. HORDE OF THE FLIES (Switch eShop)
- Earth Atlantis (Switch eShop)
- Earth Defense Force 2017 (Switch eShop)
- Earth Defense Force 2: Invaders from Planet Space (Switch eShop)
- Earth Defense Force: World Brothers (Switch eShop)
- Earth Wars (Switch eShop)
- Earthblade (Switch)
- EarthBound (SNES)
- EarthBound Beginnings (NES)
- Earthfall: Alien Horde (Switch eShop)
- Earthlock (Switch eShop)
- Earthlock: Festival of Magic (Wii U eShop)
- EarthNight (Switch eShop)
- Earthworm Jim (DSiWare)
- Earthworm Jim (GB)
- Earthworm Jim (MD)
- Earthworm Jim 2 (MD)
- Earthworm Jim 3D (N64)
- Earthworm Jim: Menace 2 the Galaxy (GBC)
- Earthworms (Switch eShop)
- Easter Eggztravaganza (DSiWare)
- Eastward (Switch eShop)
- Eat Beat Deadspike-San (Switch eShop)
- Eat your letters (Switch eShop)
- Eat! Fat! FIGHT! (WiiWare)
- Eba & Egg: A Hatch Trip (Wii U eShop)
- Ecco Jr. (MD)
- Ecco The Dolphin (MD)
- Ecco: The Tides of Time (MD)
- Ecks vs. Sever (GBA)
- Eclipse: Edge of Light (Switch eShop)
- Eco Creatures: Save the Forest (DS)
- Eco Shooter: Plant 530 (WiiWare)
- eCrossminton (Switch eShop)
- EctoPlaza (Wii U eShop)
- ECW Hardcore Revolution (GBC)
- ECW Hardcore Revolution (N64)
- Ed, Edd n Eddy: Scam of the Century (DS)
- Ed, Edd n Eddy: The Mis-Edventures (GCN)
- Edgar - Bokbok in Boulzac (Switch eShop)
- EDGE (3DS eShop)
- EDGE (Wii U eShop)
- Edna & Harvey: Harvey's New Eyes (Switch eShop)
- Edna & Harvey: Harvey’s New Eyes (Switch eShop)
- Edna & Harvey: The Breakout – Anniversary Edition (Switch eShop)
- Edo Bunka Rekishi Kentei (DS)
- Eduardo the Samurai Toaster (WiiWare)
- Educational Games For Kids (Switch eShop)
- Educational Pack of Kids Games (Wii U eShop)
- Eekeemoo - Splinters of the Dark Shard (Switch eShop)
- Effie (Switch eShop)
- Egg Mania (GBA)
- Egg Mania: Eggstreme Madness (GCN)
- Egg Monster Hero (DS)
- Eggggg - The platform puker (Switch eShop)
- Ego Protocol: Remastered (Switch eShop)
- Eight Dragons (Switch eShop)
- Eight-Minute Empire (Switch eShop)
- Eiko no Saint Andrews (N64)
- Eisei Meijin VI (GCN)
- EJ Puzzles: Hooked (DSiWare)
- El Hijo: A Wild West Tale (Switch eShop)
- El Silla - Arcade Edition (Wii U eShop)
- El Tigre: The Adventures of Manny Rivera (DS)
- Elasto Mania Remastered (Switch eShop)
- Elden: Path of the Forgotten (Switch eShop)
- Eldest Souls (Switch eShop)
- Eldrador Creatures (Switch eShop)
- ELEA: Paradigm Shift (Switch eShop)
- Elebits (Wii)
- Electro Ride: The Neon Racing (Switch eShop)
- Electronic Super Joy (Switch eShop)
- Electronic Super Joy (Wii U eShop)
- Electronic Super Joy 2 (Switch eShop)
- Electronic Super Joy: Groove City (Wii U eShop)
- Electroplankton (DS)
- Electroplankton Beatnes (DSiWare)
- Electroplankton Hanenbow (DSiWare)
- Electroplankton Lumiloop (DSiWare)
- Electroplankton Luminarrow (DSiWare)
- Electroplankton Marine-Crystals (DSiWare)
- Electroplankton Nanocarp (DSiWare)
- Electroplankton Rec-Rec (DSiWare)
- Electroplankton Sun-Animalcule (DSiWare)
- Electroplankton Trapy (DSiWare)
- Electroplankton Varvoice (DSiWare)
- Eledees: The Adventures of Kai and Zero (DS)
- Element (Switch eShop)
- Elemental Knights R (Switch eShop)
- Elemental Masters (DSiWare)
- Elemental Monster (DS)
- Elementallis (Switch eShop)
- Elements of Destruction (DS)
- Elevator Action (GB)
- Elevator Action (NES)
- Elevator Action EX (GBC)
- Elevator...to the Moon! Turbo Champion's Edition (Switch eShop)
- Elf Bowling 1 & 2 (DS)
- Eliminator Boat Duel (NES)
- Elite (NES)
- Elite Beat Agents (DS)
- Elite Forces: Unit 77 (DS)
- Elite Forces: Unit 77 (DSiWare)
- Elite Soccer (GB)
- Eliza (Switch eShop)
- Ellen (Switch eShop)
- Elli (Switch eShop)
- Elliot (Switch eShop)
- Elliot Quest (3DS eShop)
- Elliot Quest (Switch eShop)
- Elliot Quest (Wii U eShop)
- Ellipsis (Switch eShop)
- Elminage DS Remix: Yami no Miko to Kamigami no Yubiwa (DS)
- Elminage Original (3DS eShop)
- Elmo's Letter Adventure (N64)
- Elmo's Number Journey (N64)
- Ember (Switch eShop)
- Embers of Mirrim (Switch eShop)
- Emblem of Gundam (DS)
- Embracelet (Switch eShop)
- Emergency Heroes (Wii)
- Emergency HQ (Switch eShop)
- Emergency Room: Real Life Rescues (DS)
- Emily Archer and the Curse of Tutankhamun (Switch eShop)
- Emma at the Farm (DS)
- Emma in the Mountains (DS)
- Emma: Lost in Memories (Switch eShop)
- Emojikara: A Clever Emoji Match Game (Wii U eShop)
- Empire Invasion (Switch eShop)
- Empire of Angels IV (Switch eShop)
- Empire of Sin (Switch)
- Enchanted (DS)
- Enchanted in the Moonlight - Kiryu, Chikage & Yukinojo - (Switch eShop)
- Enchanted in the Moonlight - Miyabi, Kyoga & Samon - (Switch eShop)
- Enchanting Mahjong Match (Switch eShop)
- Ender Lilies: Quietus of the Knights (Switch eShop)
- Endless Dungeon (Switch eShop)
- Endless Fables: Dark Moor (Switch eShop)
- Endless Golf (Wii U eShop)
- Endless Ocean (Wii)
- Endless Ocean 2: Adventures of the Deep (Wii)
- Endling (Switch eShop)
- Endurance - space action (Switch eShop)
- Enduro Racer (SMS)
- Ener-G Dance Squad (DS)
- Ener-G Gym Rockets (DS)
- Ener-G Horse Riders (DS)
- Energy Balance (Switch eShop)
- Energy Cycle (Switch eShop)
- Energy Cycle Edge (Switch eShop)
- Energy Invasion (Switch eShop)
- English Training (DS)
- Enigmatis 2: The Mists of Ravenwood (Switch eShop)
- Enjoy Your Massage! (WiiWare)
- Enter the Gungeon (Switch eShop)
- Enter the Matrix (GCN)
- Ephemeral -Fantasy On Dark- (Switch eShop)
- Epic Astro Story (Switch eShop)
- Epic Chef (Switch eShop)
- Epic Clicker Journey (Switch eShop)
- Epic Dumpster Bear (Wii U eShop)
- Epic Loon (Switch eShop)
- Epic Word Search Collection (3DS eShop)
- Epic Word Search Collection (Switch eShop)
- Epic Word Search Collection 2 (3DS eShop)
- Epic Word Search Collection 2 (Switch eShop)
- Epic Word Search Holiday Special (3DS eShop)
- Epitaph (Switch eShop)
- EQI (Switch eShop)
- EQQO (Switch eShop)
- Equestrian Training (DS)
- Equilibrio (WiiWare)
- Equinox (SNES)
- Eragon (DS)
- Escape 2088 (Switch eShop)
- Escape Doodland (Switch eShop)
- Escape First (Switch eShop)
- Escape First 2 (Switch eShop)
- Escape First 3 (Switch eShop)
- Escape from Chernobyl (Switch eShop)
- Escape From Flare Industries (Wii U eShop)
- Escape from Life Inc (Switch eShop)
- Escape From Tethys (Switch eShop)
- Escape from the Universe (Switch eShop)
- Escape From Zombie City (3DS eShop)
- Escape Game Fort Boyard (Switch eShop)
- Escape Game: Aloha (Switch eShop)
- Escape Route (Switch eShop)
- Escape The Virus: Shoot 'Em Up! (DSiWare)
- Escape the Virus: Swarm Survival (DSiWare)
- Escape Trick: 35 Fateful Enigmas (Switch eShop)
- Escape Trick: Convenience Store (DSiWare)
- Escape Trick: Ninja Castle (DSiWare)
- Escape Trick: The Secret of Rock City Prison (DSiWare)
- Escape! Zombie City (3DS eShop)
- Escapee GO! (DSiWare)
- escapeVektor (3DS eShop)
- escapeVektor: Chapter 1 (WiiWare)
- Escaping a Kid's Room～The Adventures of Nyanzou&Kumakichi: Escape Game Series～ (Switch eShop)
- ESP Ra.De. Psi (Switch)
- Espacio Cosmic Light-Seeker (Switch eShop)
- ESPN International Track & Field (GBC)
- ESPN International Winter Sports 2002 (GCN)
- ESPN MLS ExtraTime 2002 (GCN)
- ESPN National Hockey Night (GBC)
- ESPN Sports Connection (Wii U)
- ESport Manager (Switch eShop)
- eSports Legend (Switch eShop)
- Esports Life Tycoon (Switch eShop)
- Essential Sudoku (DS)
- Estiman (Switch eShop)
- Estranged: The Departure (Switch eShop)
- ESWAT: City Under Siege (MD)
- Eternal Card Game (Switch eShop)
- Eternal Champions (MD)
- Eternal Darkness: Sanity's Requiem (GCN)
- Eternal Edge (Switch eShop)
- Eternum Ex (Switch eShop)
- Ethan: Meteor Hunter (Switch eShop)
- Etherborn (Switch eShop)
- Etrian Mystery Dungeon (3DS)
- Etrian Mystery Dungeon 2 (3DS)
- Etrian Odyssey (DS)
- Etrian Odyssey 2 Untold: The Fafnir Knight (3DS)
- Etrian Odyssey II: Heroes of Lagaard (DS)
- Etrian Odyssey III: The Drowned City (DS)
- Etrian Odyssey IV: Legends of the Titan (3DS)
- Etrian Odyssey Nexus (3DS)
- Etrian Odyssey Untold: The Millennium Girl (3DS)
- Etrian Odyssey V: Beyond the Myth (3DS)
- European Conqueror 3D (3DS eShop)
- European Conqueror X (Switch eShop)
- Evan's Remains (Switch eShop)
- Evasive Space (WiiWare)
- Evel Knievel (GBC)
- Even the Ocean (Switch eShop)
- Event Horizon (Switch eShop)
- Event Horizon: Space Defense (Switch eShop)
- Ever Forward (Switch)
- Ever Oasis (3DS)
- Everdark Tower (Switch eShop)
- Evergate (Switch eShop)
- Everhood (Switch eShop)
- Everspace - Stellar Edition (Switch eShop)
- Everybody, Hearts! (Switch eShop)
- Everyday Soccer (DSiWare)
- Everyday♪ Today's MENU for EMIYA Family (Switch eShop)
- Everything (Switch eShop)
- Evil Dead: The Game (Switch)
- Evil Defenders (Switch eShop)
- Evil Inside (Switch eShop)
- Evofish (Wii U eShop)
- Evoland Legendary Edition (Switch eShop)
- Evolution Board Game (Switch eShop)
- Evolution Skateboarding (GCN)
- Evolution Snowboarding (GCN)
- Evolution Worlds (GCN)
- Ex Oblivione (Wii U eShop)
- Excave (3DS eShop)
- Excave II : Wizard of the Underworld (3DS eShop)
- Excave III : Tower of Destiny (3DS eShop)
- Exception (Switch eShop)
- Excite Truck (Wii)
- Excitebike (NES)
- Excitebike 64 (N64)
- Excitebike: World Rally (WiiWare)
- Excitebots: Trick Racing (Wii)
- Exed Exes (VC Arcade)
- Exertainment Mountain Bike Rally / Speed Racer (SNES)
- Exhaust Heat (SNES)
- Exile's End (Wii U eShop)
- Exit (DS)
- Exit the Gungeon (Switch eShop)
- Exodemon (Switch eShop)
- Exorder (Switch eShop)
- Exploding Kittens (Switch eShop)
- Explody Bomb (Wii U eShop)
- Explosionade DX (Switch eShop)
- Explosive Dinosaurs (Switch eShop)
- Explosive Jake (Switch eShop)
- Extra Bases (GB)
- Extreme Exorcism (Wii U eShop)
- Extreme Ghostbusters (GBC)
- Extreme Hangman (DSiWare)
- Extreme Hangman 2 (DSiWare)
- EXTREME POKER (Switch eShop)
- Extreme Sports with the Berenstain Bears (GBC)
- Extreme Trucks Simulator (Switch eShop)
- Extreme-G (N64)
- Extreme-G 2 (N64)
- Extreme-G 3 (GCN)
- Eyes: The Horror Game (Switch eShop)
- Eyeshield 21: MAX Devil Power (DS)