- I am an Air Traffic Controller Airport Hero Hawaii (3DS eShop)
- I am an Air Traffic Controller Airport Hero Narita (3DS eShop)
- I am an air traffic controller AIRPORT HERO OSAKA-KIX (3DS eShop)
- I Am In The Movie (DSiWare)
- I Am Setsuna (Switch eShop)
- I and Me (Switch eShop)
- I C REDD (Wii U eShop)
- I Heart Geeks (DS)
- I Love my Cats (3DS eShop)
- I Love My Dogs (3DS eShop)
- I Love My Horse (3DS)
- I Love My Little Boy (3DS)
- I Love My Little Girl (3DS)
- I Love My Pets (3DS)
- I Love My Pony (3DS)
- I Must Run! (DSiWare)
- I SPY Spooky Mansion (Wii)
- I've Got to Run! (Wii U eShop)
- I've Got to Run: Complete Edition! (3DS eShop)
- Ice Climber (NES)
- Ice Cream Surfer (Wii U eShop)
- Ice Hockey (NES)
- Ice Hockey Slovakia 2011 (DSiWare)
- Ice Station Z (3DS eShop)
- Igor The Game (Wii)
- Ikachan (3DS eShop)
- Ikaruga (GCN)
- Ikibago (DSiWare)
- illo: birth of the cool (3DS eShop)
- illo: birth of the cool (Wii U eShop)
- Illusion of Gaia (SNES)
- Imagine Fashion Designer (3DS)
- Imagine Me (Wii U eShop)
- Imagine: Champion Rider 3D (3DS)
- Implosion (Switch eShop)
- Impossible Mission (C64)
- Impossible Mission II (C64)
- In Between (Wii U eShop)
- Inazuma Eleven (DS)
- Inazuma Eleven (3DS eShop)
- Inazuma Eleven 2 Blizzard (DS)
- Inazuma Eleven 2 Firestorm (DS)
- Inazuma Eleven 3 (3DS)
- Inazuma Eleven 3: Team Ogre Attacks (3DS)
- Inazuma Eleven GO Chrono Stones: Wildfire & Thunderflash (3DS)
- Inazuma Eleven GO: Light & Shadow (3DS)
- Inazuma Eleven Strikers (Wii)
- Inchworm Animation (DSiWare)
- Incoming! (WiiWare)
- Indiana Jones and the Staff of Kings (Wii)
- Indiana Jones' Greatest Adventures (SNES)
- Indivisible (Switch)
- Infinite Dunamis (3DS eShop)
- Infinite Frontier Super Robot Wars OG Saga (DS)
- Infinite Golf (New 3DS)
- Infinite Minigolf (Switch eShop)
- Infinite Space (DS)
- Infinity Runner (Wii U eShop)
- Initial D: Perfect Shift Online (3DS eShop)
- Injustice: Gods Among Us (Wii U)
- Inkub (WiiWare)
- Insanity's Blade (Wii U eShop)
- Inside My Radio (Wii U eShop)
- Insmouse No Yakata (VB)
- Intellivision Lives! (GCN)
- Intellivision Lives! (DS)
- Internal Invasion (Wii U eShop)
- International Karate (C64)
- International Karate + (C64)
- International Superstar Soccer (SNES)
- INVANOID (Wii U eShop)
- Invasion of the Alien Blobs! (DSiWare)
- IQ Test (Wii U eShop)
- Iron Combat: War in the Air (3DS eShop)
- Iron Man (Wii)
- Iron Man 2 (Wii)
- Ironcast (Switch eShop)
- Ironclad (Neo Geo)
- IRONFALL Invasion (3DS eShop)
- Island Flight Simulator (Wii U eShop)
- iSpot Japan (DSiWare)
- ISS 64 (N64)
- ISS 98 (N64)
- It's My Birthday (Wii)
- Ittle Dew (Wii U eShop)
- Ittle Dew 2 (Switch eShop)
- Ittle Dew 2+ (Switch eShop)
- Ivy the Kiwi? (DS)
- Ivy the Kiwi? (Wii)
- Ivy the Kiwi? Mini (DSiWare)
- Izuna 2: The Unemployed Ninja Returns (DS)
- Izuna: Legend of the Unemployed Ninja (DS)