Zero Escape: Virtue's Last Reward is a recent 3DS release that — though unlikely to be a big-seller — will have attracted a committed group of enthusiasts that enjoyed 999: Nine Hours, Nine Persons, Nine Doors on DS. While a number of gamers are no doubt enjoying the experience and its many, many endings, it's emerged that a save-breaking bug could potentially ruin hours of play.
As discovered by a user on NeoGaf, if you save your game while in the Pressure Exchange (PEC) puzzle room or Crew's Quarters puzzle room, it can cause a corruption of your save file that can only be resolved by deleting your data and starting again; considering the fact there's only one save slot, that's a big problem. It's possible that the error can also occur in other puzzle rooms, so the advice is to save before entering them. There are other crashes that occur outside of this that kick you out of the game, but if you restart right away and check your save data you may, if the gaming Gods are smiling on you, be fine to resume your game.
At the time of writing there's no suggestion of a patch from publisher Aksys Games — the bug is only on 3DS, not PS Vita — and it's an issue that was in the Japanese release from February this year. It's disappointing that it wasn't resolved before localisation, and based on its presence in the North American version we expect the same problem to exist in the European equivalent, which arrives on 16th November.
So remember, don't save in any puzzle rooms.