On the eve of the one-year anniversary of their defeating the Syndicate, Blaze, Adam and Axel met up for drinks. The morning after, Axel receives a frantic phone call from Eddie 'Skate' Hunter, Adam's younger brother, who lives with him on the edge of the city. Blaze and Axel then find Adam and Skate's house wrecked, and a picture of Adam chained to a wall at the feet of Mr. X.
The city has once again returned to its former nightmarish state, with the city streets, roads and parks swarming with criminals. Unable to contact their old friend in artillery, Axel and Blaze team up with Skate and Max Thunder, an old friend of Axel's, to free the city and rescue Adam from the Syndicate's private island. It is up to you to take down Mr. X once and for all!