Konami producer Dave Cox has already stated that a Wii U version of Castlevania: Lords of Shadow 2 isn't going to happen, but he's never really elaborated on the reason why - until now, that is.
Speaking to Dutch site n1ntendo.nl, Cox had this to say:
The reason that we're not making a Wii U-version of Castlevania: Lords of Shadow 2 is because of our resources. We have a limited amount of people working on the title. About 60 people worked on the first title and that's a pretty small team. With the sequel we have slightly expanded that team, but in order to make a Wii U-version, we need about 20 to 30 extra people. Next to that, we're already pretty far into the development of Lords of Shadow 2, so it would be very hard for us to work on a Wii U-version without negatively effecting the general development of the title. That's the only reason there won't be a Wii U-version, it's not that we don't want to make it, it's just that it wouldn't make sense for us to do so right now.
He also responded to web chatter regarding the possibility of a home console version of Castlevania: Lords of Shadow - Mirror of Fate, which was started by the fact that he mentioned that MercurySteam have HD assets for the game:
The reason we've first made Castlevania: Lords of Shadow - Mirror of Fate in HD to then downscale the graphics to the 3DS is because it ensures that the quality of the images is maintained. It's a common technique when making videogames. We used a lot of PC's while developing the Nintendo 3DS-game, but that doesn't mean there's also a PC-version coming.
Eventhough we've got HD-assets of the game, the game is pretty much designed for the Nintendo 3DS. It's always been our focus and intention to the release the game for that platform. We have no plans to bring the game to HD-consoles. We have no plans to create a different version. The game is pretty much designed to play with the dual screens and to use the capabilities of the 3DS.
It's not uncommon for developers to save the HD-assets of a game to possibly use them in future projects, but at this time we've got nothing planned.
We actually kind of like the fact that Mirror of Fate is remaining exclusive to the 3DS — sure, we'd have loved to have played a HD version, but it sounds like Konami and MercurySteam are cooking up some really cool 3D-related surprises for the game.