We all know that there's a certain "sweet spot" we have to be positioned in if we are going to get the best out of the 3D effect on the 3DS, but what else can we do to make the visuals really jump out at you? According to Masahiro Sakurai, not fidgeting would help.
The Project Sora director behind the upcoming Kid Icarus: Uprising has been tweeting responses to his followers lately, one of which was in relation to the effect shaky hands can have on the machine's 3D output. By no means mandatory requirements, Sakurai suggests keeping the 3DS still and adjusting the slider to prevent eyes from tiring.
From Nintendo Life's hands-on time with the 3DS, we can tell you that the aforementioned "sweet spot" is a decent size so unless you're moving erratically for whatever reason, you shouldn't miss out on the 3-dimensions too easily. Perhaps you should think of it as trying to read a newspaper on a bumpy train; it can cause minor blurring, but it's still feasible and the end of the world is still a way away.