When Zelda: Twilight Princess made the jump from GameCube to Wii, some fans of the green-clad hero were unhappy that the game was completely flipped from left to right to accommodate many players being right-handed. With the unveiling of Zelda: Skyward Sword only one week old – doesn't time fly? – those old wounds may be reopened as a recent report suggests Link will be staying right-handed only in his next adventure.
An article on gaming blog Wild Gunmen quotes Nintendo representative Julie Gagnon as stating that "left-handed controls are not currently planned", and you'll notice that in all the currently-released artwork Link is holding the sword right-handed.
There's still plenty of development time between now and the game's release next year, but for now it might be wise to start practising ambidexterity.