Punch Out!! Wii was pretty sweet, so news of a sequel is welcome indeed. Bryce Holliday of Next Level Games - the developer behind the pugilistic masterpiece - has gone on record saying that he'd love to create a follow up, but those of you expecting a traditional sequel which merely updates the fighter roster and adds little to the gameplay are going to be disappointed - innovation is the key here.
Holliday had this to say about how the company would handle such a proposition:
Cooperative, competitive multiplayer support or create-a-boss mode would be places to start, but we'd need to come up with a new 'hook' like the motion controllers gave us in this iteration.
Indeed, Nintendo producer Kensuke Tanabe has stated that the company is "not planning a sequel where simply the fighters are replaced" and that any new Punch Out!! title will be an all-new affair. Sounds exciting!