"Im gonna rip your mutha******* balls off" House of Dead Overkill

A stroke of genius.

"Infinite ammo." -- Solid Snake, MGS2

Honestly it cracks me up every time I play Onslaught.
'' Thats why your still a kid''

"I love going on message boards and complaining about games I've never played!" - Super Paper Mario
"GET UP ON THE HYDRAS BACK!!" -Kingdom Hearts II
It's time to kick @$$ and chew bubblegum...and I'm all out of gum -Duke Nukem

Anything from Overkill...although it does become a little overdone.
Also, mainly because it was the most memorable scene from MGS2: "Emma...? Damn...!" If you've played it, you know exaclty what I'm talking about. Insert tears...unless that sniping level was a pain for you.

Doc Lois says something similar to "Where is a plumber when you need one?", in Punch Out when you fight DK. I think that is pretty awesome.

Anything of the CDi Nintendo games. So bad it makes you laugh.

I AM ERROR.-Error in Zelda II (I think it was Zelda II)

Anything Fawful says. That guy is pure comedic gold.

What? You fight Donkey Kong? The whole game is now ruined for me!

Hey, I didn't even know until I bought my Nintendo Power calender. It was ruined for me, too.

Echo what Ricardo said. I can't pick a favorite, but here's some of his best:

"I HAVE CHORTLES!"

"Beef? I am lacking in beef. Fawful is beefless."

"I drizzled rage dressing on the country next door. Rage dressing on a salad of evil!"

"Your lives that I spit on are now but a caricature of a cartoon drawn by a kid who is stupid!"

"I am the great Cackletta's most best pupil, who is named Fawful! I am here, laughing at you! If you are giving us the chase, just to get your silly princess's voice, then you are idiots of foolishness! Princess Peach's sweet voice will soon be the bread that makes the sandwich of Cackletta's desires! And this battle shall be the delicious mustard on that bread! The mustard of your doom!"

@pixelman
"You inhaled like a hungry syrup pig at the free pancake buffet".
There's better ones, but thats the only one that comes to mind at the moment.

"I'm Luigi number 1" Mario Kart 64.

"A Winner is You"
"All Your Base Are Belong to Us"
"What is a Man? A miserable little pile of secrets! But enough talk! Have at you!!"

"Dinosaurs... huge aren't they? Well, that's all I've gotten out of my research."
Mr. Spoon, Fourside Museum's leading scholar
(Earthbound)

"Wake up Mr Freeman, and smell the ashes."

"Thank you so much for to playing my game"

"Remember when the platform was sliding into the fire pit and I said "Goodbye" and you were like "No way!" And then I was all "We pretended we were going to murder you?" That was great!"

"Your face. Your ass. What's the difference?"

Arcana:
Salah: "Wait, there's a door!"
Axs: "Be careful! It could be a trap."
Salah: "If it is a trap, then I'll fall into the trap"

Best mistranslation quote ever!!

"War. War never changes." Those words sends chills down the spine to anyone who has played the Fallout games. Ron Perlman voice and those words will always be remember by millions of gamers.

glances at Zero Wing