Freshly escaped from the winds of Flotsam Island, this second chapter picks up right where we first left our intrepid hero: with the blade of an unknown woman against his throat! But this is only the beginning…

Guybrush's adventures on the high seas continue as pox-plagued pirates lay siege to the innocent Mer-People. In between defending the Mer-People and dodging the persistent pirate hunter hot on his trail, Guybrush manages to catch up to his beloved wife Elaine and despised arch-nemesis LeChuck - the more heart-warming of those two reunions proving to be painfully short-lived.