Say bye to Ripley and hello to Halliwell.

Turn-of-the-90's teen heartthrob Alyssa Milano has been tapped to replace Sigourney Weaver as the female lead in Atari's upcoming multi-platform Ghostbusters video game.

The 36-year-old actress, best known for her roles in television series "Charmed" and "Who's The Boss?", takes the place of original Ghostbusters cast member Sigourney Weaver, who initially declined the role due to concerns about the quality of the game. By the time fellow cast-member Bill Murray convinced her that the project was the real deal Weaver's character had been written out of the script. You snooze, you lose.

Milano had this to say about replacing Weaver's character:

Obviously, fans of the movie are going to miss Sigourney Weaver. I have so much respect for that character in the movie that I hope I do the position that she is in justice. I was just flattered to be asked to be part of Ghostbusters.

Milano will provide the voice of Dr. Ilyssa Selwyn, curator of the "World Of Gozer" exhibit at New York City's Natural History Museum. The script, co-written by Dan Akroyd and Harold Ramis, takes place after the events of the second Ghostbusters film and includes the entire cast of the original, sans Weaver and Rick Moranis, who we can only assume is holed up in a golden fortress somewhere counting the profits from "Honey, I Shrunk The Kids".

Ghostbusters: The Video Game is set for a 2009 release on the Xbox 360, Playstation 3, Nintendo Wii, Nintendo DS, Playstation 2 and PC. Expect more updates and previews here at Nintendo Life as the game nears release. Until then why not read our review of Mushroom Men? It was created and developed by Red Fly Studio, the same guys who are doing the Wii version of Ghostbusters.