There's a few I like, but here's a random one:

"I hope she made lotsa spaghetti!"

• Luigi

"Don't go to heaven!" - Blue Blue Cultist(Earthbound)

The one that Pandora says in God of War III about hope and stuff.

Also, what that one cop in RE2 says when you run into him with Leon. Something about how his welcome party was cancelled because of the zombie out break.

I'm sure I could think of more, but those are the ones that came to mind first.

"Honesty is the key to any relationship. If you can fake that, you're set."
~ Dragon Quest VII

Bogard is a queer old man-narrator from FINAL FANTASY Adventure

Memories are great...but that's all they are-Rikku from FINAL FANTASY X

You? With a woman? You can't even catch a ball-Jecht FINAL FANTASY X

"I'm sweatin' like a hooker in church." - Victor Sullivan (Uncharted 2)

"Time passes, people move.... Like a rivers flow, it never ends... A childish mind will turn to noble ambition... Young love will become deep affection... The clear water's surface reflects growth... Now listen to the Serenade of Water to reflect upon yourself...." - Sheik (Legend of Zelda: Ocarina of Time)

"Some trees flourish, others die. Some cattle grow strong, others are taken by wolves. Some men are born rich enough and dumb enough to enjoy their lives. Ain't nothing fair. You know that." - John Marston (Red Dead Redemption)

"You and West Dickens are so crooked you could swallow nails and spit out corkscrews." - John Marston (Red Dead Redemption)

"How does it feel, Wayne? To stand on the very stone that ran with your parents' blood? Do you feel sad? Full of rage? Or does that outfit help bury your feelings? Hiding your true self. You're truly an extraordinary specimen... I look forward to breaking you." - Hugo Strange (Batman: Arkham City)

I HAVE FURY!!!!!!

by Fawful(M&L series)

Prepare for trouble
by Team Rocket(Jessie, James and Meowth in Pokémon Puzzle League)

"Relatioships are the essence of society' -Aaron Boreal(Megaman Star Force)

Witness the Logos of Judgment, and judge you I will. - Absin (Arc Rise Fantasia)