Weren't there talk about 3DS having the possibility to install games? If games are downloaded from an online store, it could pretty much mean the end of pirating on their next handheld (if digital distribution is all there is and no cartridges, which I doubt will happen btw).
This could very well be the anti-piracy measures nintendo is pondering on taking.

Wait... only 2-player support online? No 4-player co-op? How can you possibly have a game with 4 unique characters like this and only allow 2 to play together online? Without that it's definitely not "Left 4 Dead" on the Wii, and I'll definitely be passing.

I'm not quite sure how High Voltage could do 12-player death matches with Conduit (and have them running quite smoothly) but not be able to do 4-player online co-op in Grinder. Please someone tell me I just misinterpreted this article...