One of the most self-explanatory game names you could ask for, in I Must Run! you must run.
Gamelion's skyscraper scamper has already been released on PlayStation Minis and mobile phones but is coming to DSiWare in the near future. If you've played Canabalt you'll have a fairly good idea what to expect, though I Must Run! includes a story mode to complete and six different challenge stages.
Perhaps trumping I Must Run! in the obvious names department is the studio's other DSiWare announcement, Aahh! Spot the Difference. You can probably guess what that's about. Both titles are due for release in the next few months.