Melee!!!!!! - Announcer (Picking Melee as a a game mode) (Super Smash Bros. Melee)

The last Metroid is in captivity...the galaxy is at peace. Cue Music

"Fixed Camera!!" - Announcer (Super Smash Bros. Melee)

This isn't really a quote but when the black Mage gives the dead monsters the finger in final fantasy 1 it is to die for.

"Heroes of white! Your time has come!" -StreetPass Quest

Not really fantastically memesical, but it sounds cheesily awesome enough.

I love that. I cracked up when I read it. He was addressing me without even knowing it. If you had the option Animal Crossing-style, I would've told him I was that ocarina kid.

"Lets Dance Boys!" - Bayonetta

"Get realy real!" - Amitie, Puyo Pop Fever

"Your the greatest" - Silent Scope Complete

And something about a "Jill Sandwhich" from a Resident evil game...

Hmm... a DINE-ing room.

This from Kefka:

http://www.youtube.com/watch?v=PG7lvNkyPZs

Kefka.. My most favorite villain in the Final Fantasy series.

Kefka is #2. Sephiroth is #1!

WHAT IS A MAN? A MISERABLE PILE OF SECRETS! - Castlevania: Symphony of the Night

In a similar vein:
"You're words are as empty as your soul! Mankind ill needs a savior like you!" - I Wanna Be the Guy

"We're talking guys who beat off four times a day!" - Andrei Ulmeyda from Killer7

"Its so bad the rating will go up. Do you want the game to be delayed and be called No More Heroes Forever?" - Jeane from No More Heroes.

"When you see your brother in hell, tell him he's still a douche!" - Travis Touchdown to Skelter Helter

"It's called being fashionably late, f***face!" Travis Touchdown (No More Heroes 2)

...yeah, I like Suda51

...and

"Nobody calls me that anymore!" - Dr. Eggman, upon being called 'Dr. Robotnik by classic Tails in Sonic Generations

Anything from waverace 64 is golden

"And then, he falls to his death...I'm just foolin'!"

...Or anything else Rucks says in Bastion, anyway.

tales of the abyss: asch: well said. i will make those words ur last. REPLICA!!

http://www.youtube.com/watch?v=TRtpmVyezyE

"TWO GUNS, B*TCH!!!"
-Two-Face to Catwomen in ARKHAM CITY

FLYNN LIVES

I am Error.

I liked that. My computer was so laggy w/ it, so I couldn't quite get that until now though...

BioShock has some good ones:
"We all make choices, but in the end it's out choices that make us."- Andrew Ryan
"Would you kindly?"